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AS 35

a leukotriene receptor antagonist

Also Known As:

9-((4-acetyl-3-hydroxy-2-propylphenoxy)methyl)-3-(1H-tetrazol-5-yl)-4H-pyrido(1,2-a)pyrimidin-4-one; AS 35 potassium salt; AS-35

Networked: 206 relevant articles (5 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds

Experts

1.	Preedy, Victor R: 3 articles (07/2006 - 06/2002)
2.	Ferriani, Rui Alberto: 2 articles (01/2019 - 08/2015)
3.	Montenegro, Mary Lourdes: 2 articles (01/2019 - 08/2015)
4.	Adachi, Junko: 2 articles (06/2002 - 06/2002)
5.	Ueno, Yasuhiro: 2 articles (06/2002 - 06/2002)
6.	Bassat, Quique: 1 article (06/2022)
7.	Bates, Matthew: 1 article (06/2022)
8.	Buck, W Chris: 1 article (06/2022)
9.	Burger, David: 1 article (06/2022)
10.	Castillo, Lola Madrid: 1 article (06/2022)

Related Diseases

1.	Asthma (Bronchial Asthma) 11/01/2002 - "Atopic dermatitis was reported by 19/248 (7.7%) patients with AS, 26/536 (4.9%) controls, and 14/487 (2.9%) patients with RA (p=0.003 for AS v RA), and asthma by 18/248 (7.3%) patients with AS, 35/536 (6.5%) controls, and 21/487 (4.3%) patients with RA. " 06/01/1992 - "From these results, it is suggested that AS-35 is effective against allergic asthma through antagonism towards peptide-LTs released anaphylactically in addition to inhibition of the chemical mediator release." 06/01/1994 - "These results suggest that sulfidopeptide leukotrienes (s-LTs) play an important role in the allergic bronchoconstriction in guinea pigs pretreated with antihistamine, and AS-35 inhalation may be beneficial in the treatment of asthma."
2.	Pneumonia (Pneumonitis) 06/27/2022 - "Pneumonia is the primary cause of death among HIV-infected children in Africa, with mortality rates as high as 35-40% in infants hospitalized with severe pneumonia. " 09/01/2010 - "In Papua New Guinea (PNG), an effective oxygen system that improved the detection and treatment of hypoxaemia in provincial and district hospitals reduced death rates from pneumonia in children by as much as 35%. " 11/01/2019 - "Despite the introduction of effective antibiotics and intensive supportive care in the 20th century, death rates from community-acquired pneumonia among patients in the intensive care unit remain as high as 35%. "
3.	Cicatrix (Scar) 10/01/2019 - "The participating patients were divided into two groups as 35 patients with ischemia and 34 patients with scar tissue based on the results of the myocardial perfusion scintigraphy. " 01/01/1999 - "This revealed that 120 of the 253 cross-sectioned fascicles in PEN lacked axon and only 5% of the fascicles had an axon to schwann cell nuclear ratio greater than 1:2. In contrast, all fascicles in 40 dermal nerves adjacent to PENs as well as 35 traumatic neuromas in surgical scars had an axon to schwann cell nuclear ratio of at least 1:2 and the majority a ratio of 1:1 or higher. " 01/01/2001 - "Thirty-one patients with melasma, 4 with superficial post acne scarring and one each with xeroderma pigmentosum and epidermal naevus were studied to know the efficacy of glycolic acid for chemical peeling in varying concentrations and time intervals such as 35% (4 minutes), 52.5% (3 minutes), 70% (2 minutes) at varying intervals upto 6 months. "
4.	Overactive Urinary Bladder (Overactive Bladder) 07/01/2010 - "To evaluate the urodynamic effects of fesoterodine, a new antimuscarinic agent, alone and combined with doxazosin, in a rat model of partial urethral obstruction (PUO), as 35-83% of men with bladder outlet obstruction (BOO) secondary to benign prostatic hyperplasia (BPH) have overactive bladder (OAB) syndrome, and as the combination of alpha(1)-adrenoceptor- and muscarinic-receptor antagonists has been proposed to be beneficial for these patients. "
5.	Xeroderma Pigmentosum (Kaposi's Disease) 01/01/2001 - "Thirty-one patients with melasma, 4 with superficial post acne scarring and one each with xeroderma pigmentosum and epidermal naevus were studied to know the efficacy of glycolic acid for chemical peeling in varying concentrations and time intervals such as 35% (4 minutes), 52.5% (3 minutes), 70% (2 minutes) at varying intervals upto 6 months. "

Related Drugs and Biologics

1.	Muscarinic Antagonists
2.	Doxazosin (Cardura)
3.	Leukotrienes
4.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
5.	Peptides (Polypeptides)
6.	Oxygen (Dioxygen)
7.	Histamine Antagonists (Antihistamines)
8.	fesoterodine
9.	glycolic acid (glycolate)
10.	Retinaldehyde (Retinal)

Related Therapies and Procedures

1.	Herniorrhaphy
2.	Cardiopulmonary Resuscitation (CPR)
3.	Liver Transplantation
4.	Kidney Transplantation
5.	Transplantation