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RO 23-6152

Also Known As:

(+)-cis-3-(acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-5-(2-(dimethylamino)ethyl)naptho-(1,2-b)-1,4-thiazepin-4(5H)one hydrochloride; R023-6152; R0236152; RO-23-6152; RO236152

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Diltiazem: 2789
        RO 23-6152: 2

Related Diseases

1.	Thrombosis (Thrombus) 10/01/1991 - "The results indicate that both R023-6152 and diltiazem are effective in suppressing in vivo platelet aggregation associated with occlusive coronary thrombus formation."
2.	Coronary Thrombosis 10/01/1991 - "In this study, we compared the platelet antiaggregatory effects of R023-6152, a thiazepinone-type calcium antagonist, with diltiazem in an in vivo canine model of spontaneous coronary thrombosis. "
3.	Coronary Occlusion 10/01/1991 - "Dogs receiving intravenous (i.v.) R023-6152 (200 micrograms/kg) or diltiazem (50 micrograms/kg) immediately after the current was discontinued exhibited no significant elevations in 5-HT values (12.3 +/- 1.4 and 1.84 +/- 0.42 ng/ml for R023-6152 and diltiazem, respectively) or development of coronary occlusions in the next 3 h. "
4.	Essential Hypertension 01/01/1991 - "Hemodynamic effects of Ro 23-6152 in patients with essential hypertension." 01/01/1991 - "In a double blind study 8 patients with uncomplicated essential hypertension received in random order single oral doses of placebo and 10, 30 and 80 mg Ro 23-6152, a novel calcium entry blocker, on 4 different days. "

Related Drugs and Biologics

1.	Diltiazem (Cardizem)
2.	Calcium
3.	Serotonin (5 Hydroxytryptamine)