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S-methyl N,N-diethylthiolcarbamate sulfoxide

structure given in first source; a natural metabolite of disulfiram; a potent inhibitor of rat liver mitochondrial aldehyde dehydrogenase
Also Known As:
DETC-MeSO; MeDTC-sulfoxide; methyl diethylthiocarbamate sulfoxide
Networked: 7 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Prentice, Howard: 3 articles (01/2017 - 01/2013)
2. Wu, Jang-Yen: 3 articles (01/2017 - 01/2013)
3. Chen, Po-Chih: 2 articles (01/2017 - 01/2013)
4. Genova, Rafaella: 2 articles (01/2017 - 10/2014)
5. Gharibani, Payam M: 2 articles (01/2017 - 01/2013)
6. Ma, Zhiyuan: 2 articles (01/2017 - 10/2014)
7. Menzie, Janet: 2 articles (01/2017 - 10/2014)
8. Modi, Jigar: 2 articles (01/2017 - 10/2014)
9. Pan, Chunliu: 2 articles (01/2017 - 01/2013)
10. Tao, Rui: 2 articles (01/2017 - 10/2014)

Related Diseases

1. Stroke (Strokes)
10/01/2014 - "Then, DETC-MeSO was administered subcutaneously for 4 and 8 days with the first injection occurring 1 h before or 24 h after reperfusion in the rat middle cerebral artery occlusion stroke model. "
01/01/2017 - "Analysis of ER stress markers pPERK, peIF-2-alpha and cleaved ATF-6 all showed decreased expression demonstrating that all 3 ER stress pathways were inhibited concurrent with a synergistic protective effect by the post-stroke administration of this DETC-MeSO-taurine combination treatment."
10/01/2014 - "Mode of action of S-methyl-N, N-diethylthiocarbamate sulfoxide (DETC-MeSO) as a novel therapy for stroke in a rat model."
08/06/2015 - "We have recently reported on the efficacy of an N-methyl-d-aspartate (NMDA) receptor partial antagonist, S-Methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), in improving outcome following stroke, including reduced infarct size and calcium influx, suppressing the endoplasmic reticulum (ER) stress-induced apoptosis as well as improving behavioral outcome. "
01/01/2013 - "Recently, we have found that several agents including granulocyte colony-stimulating factor (G-CSF), a stem cell enhancer and facilitator;S-methyl-N-diethylthiolcarbamate sulfoxide (DETC-MeSO), an NMDA receptor partial antagonist; sulindac, a potent antioxidant; and taurine, a neuroprotectant and calcium regulator, are effective in protecting against stroke-induced neuronal injury when used alone or in combination in both animal and tissue/cell culture models. "
2. Infarction (Infarctions)
3. Brain Ischemia (Cerebral Ischemia)
4. Ischemic Stroke
5. Seizures (Absence Seizure)

Related Drugs and Biologics

1. Taurine
2. N-Methylaspartate (NMDA)
3. N-Methyl-D-Aspartate Receptors (NMDA Receptors)
4. Calcium
5. S-methyl N,N-diethylthiolcarbamate sulfoxide
6. Spectrin
7. Neuroprotective Agents
8. sulfoxide
9. Granulocyte Colony-Stimulating Factor (G-CSF)
10. Sulindac (Copal)

Related Therapies and Procedures

1. Therapeutics