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KT-6124

structure given in first source; an analog of K-252a; inhibits DNA and RNA synthesis by inducing apparent DNA single-strand breaks

Also Known As:

KT 6124; KT6124

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        KT-6124: 1
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - KT-6124: 1

Related Diseases

1.	Sarcoma 180 01/01/1992 - "KT6124 was also active against sarcoma 180 and B16 melanoma. "
2.	Neoplasms (Cancer) 01/01/1992 - "These results indicate that KT6124 exerts antitumor activity by acting on DNA or on DNA-related enzyme(s) in tumor cells rather than via the inhibition of protein kinases."
3.	Experimental Melanoma 01/01/1992 - "KT6124 was also active against sarcoma 180 and B16 melanoma. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/1992 - "To determine the mechanism(s) of action underlying the antitumor activity of KT6124, we tested the drug for inhibition of protein kinases, including Ca(2+)- and phospholipid-dependent protein kinase (PKC), in intact A431 human epidermoid carcinoma cells in comparison with the PKC-inhibitory activity of K-252a. "

Related Drugs and Biologics

1.	Protein Kinases (Protein Kinase)
2.	Phospholipids (Phosphatides)
3.	Enzymes
4.	DNA (Deoxyribonucleic Acid)
5.	staurosporine aglycone (K252a)