protein-tyrosine kinase c-src

human protein-tyrosine kinase lacking the equivalent to the regulatory Tyr(527) & the autophosphorylation site at Tyr(416) of pp60 (c-src); amino acid sequence given in first source; DO NOT CONFUSE with MH PROTO-ONCOGENE PROTEIN PP60(C-SRC) which is a member of the src family; csk is not a member

Also Known As:

Networked: 83 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Okada, Masato: 3 articles (05/2011 - 03/2007)
2.	Sanjay, Archana: 3 articles (01/2011 - 04/2004)
3.	Defilippi, Paola: 2 articles (01/2013 - 03/2004)
4.	Cabodi, Sara: 2 articles (01/2013 - 03/2004)
5.	Turco, Emilia: 2 articles (01/2013 - 03/2004)
6.	Chhikara, Bhupender S: 2 articles (01/2012 - 06/2011)
7.	Kumar, Anil: 2 articles (01/2012 - 06/2011)
8.	Tiwari, Rakesh: 2 articles (01/2012 - 06/2011)
9.	Rao, V Kameshwara: 2 articles (01/2012 - 06/2011)
10.	Shirazi, Amir Nasrolahi: 2 articles (01/2012 - 06/2011)

Related Diseases

1.	Neoplasms (Cancer) 01/22/2010 - "The nonreceptor protein-tyrosine kinase c-Src is frequently overexpressed and/or activated in a variety of cancers, including those of the breast. " 10/01/2006 - "The increased expression of c-Src kinase and pStat3 expression could play a role in the invasiveness of group 2 tumors. " 10/01/2006 - "Group 2 (invasive) RB showed high c-Src kinase immunoreactivity (Allred score 6-8) in 22/22 tumors and high pStat3 (Allred score 6-8) in 19/22 tumors. " 10/01/2006 - "Group 1 (non-invasive) RB showed intermediate c-Src kinase immunoreactivity (Allred score 4-5) in 14/18 tumors and low immunoreactivity (Allred score 2-3) in 4/18 tumors. " 10/01/2006 - "The immunoreactivity of c-Src kinase and pStat3 was compared in the two groups of tumors. "
2.	Osteoporosis 04/01/2009 - "c-Src kinase play an important role in cell growth and differentiation and its inhibitors can be useful for the treatment of various diseases, including cancer, osteoporosis, and metastatic bone disease. "
3.	Bone Diseases (Bone Disease) 04/01/2009 - "c-Src kinase play an important role in cell growth and differentiation and its inhibitors can be useful for the treatment of various diseases, including cancer, osteoporosis, and metastatic bone disease. "
4.	Breast Neoplasms (Breast Cancer) 09/01/2007 - "These results indicate a crucial role for c-Src kinase in the survival of ER-positive breast cancer cells only when ER function is blocked. " 11/19/2010 - "In this study, we investigated hyaluronan (HA)-induced CD44 (a primary HA receptor) interaction with c-Src kinase and the transcriptional factor, Twist, in breast tumor cells (MDA-MB-231 cells). " 03/19/2004 - "In this study we report that OPN induces alpha(v)beta(3) integrin-mediated c-Src kinase activity in both highly invasive (MDA-MB-231) and low invasive (MCF-7) breast cancer cells. " 12/29/2000 - "Our findings indicate that PTP1B is the primary protein-tyrosine phosphatase capable of dephosphorylating c-Src in several human breast cancer cell lines and suggests a regulatory role for PTP1B in the control of c-Src kinase activity." 04/01/2011 - "HCB is a tumor cocarcinogen in rat mammary gland and an inducer of cell proliferation and c-Src kinase activity in MCF-7 breast cancer cells. "
5.	Inflammation 09/01/2007 - "These data suggest that post-translational modification of Ca(2+) channels during inflammation, possibly nitrotyrosylation, prevents c-Src kinase regulation resulting in decreased Ca(2+) influx." 09/01/2007 - "Neither the Ca(2+) channel Ca(v)1.2b, gene expression, nor the c-Src kinase activity was altered by inflammation. " 02/01/2004 - "C-terminal SRC kinase controls acute inflammation and granulocyte adhesion." 03/01/2010 - "Tyrosine nitration of Ca(2+) channels attenuates interactions with c-Src kinase, decreasing Ca(2+) channel currents and smooth muscle contraction during colonic inflammation. " 12/01/2004 - "These studies suggest that decreased calcium channel currents following colonic inflammation are not due to decreased expression but may result from altered regulation by the non-receptor cellular tyrosine kinase, c-src kinase."

Related Drugs and Biologics

1.	Hyaluronic Acid (Hyaluronan)
2.	Protein-Tyrosine Kinases (Tyrosine Kinase)
3.	Proteins (Proteins, Gene)
4.	Integrin beta3 (GPIIIa)
5.	Calcium Channels (Calcium Channel)
6.	Phosphotransferases (Kinase)
7.	Tyrosine (L-Tyrosine)
8.	Estrogens (Estrogen)
9.	Carrier Proteins (Binding Protein)
10.	Cathepsin K

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Castration