SDZ MKS 492

Also Known As:

(8-(1-(3,4-dimethoxyphenyl)-2-hydroxyethyl)amino)-3,7-dihydro-7-(2-methoxyethyl)-1,3-dimethyl-1H-purine-2,6-dione; MKS 492; MKS-492; SDZ MKS-492; 1H-Purine-2,6-dione, 8-((1-(3,4-dimethoxyphenyl)-2-hydroxyethyl)amino)-3,7-dihydro-7-(2-methoxyethyl)-1,3-dimethyl-, (R)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        SDZ MKS 492: 2

Related Diseases

1.	Spasm (Spasms) 01/01/1991 - "SDZ MKS 492 (R(+)-(8-[( 1-(3,4-Dimethoxyphenyl)-2-hydroxyethyl)amino]-3,7-dihydro-7-(2- methoxyethyl)-1,3-dimethyl-1H-purine-2,6-dione) relaxes airway smooth muscle in vitro and impairs, or reverses, spasm of guinea-pig airways in vivo. "
2.	Hypersensitivity (Allergy) 12/01/1993 - "Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats."
3.	Eosinophilia 12/01/1993 - "4) MKS-492 inhibited leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs. "
4.	Bronchial Spasm 01/01/1991 - "Effects on bronchospasm in the guinea-pig may additionally include actions on airway hyperreactivity, since SDZ MKS 492 can inhibit the development, or expression, of airway hyperreactivity due to infusion of PAF, (+/-)isoprenaline, endotoxin or injection of immune complexes. "
5.	Asthma (Bronchial Asthma) 01/01/1991 - "SDZ MKS 492 offers the prospect of a monotherapy for asthma, combining bronchodilator and anti-inflammatory activities with prophylactic efficacy."

Related Drugs and Biologics

1.	Leukotriene B4
2.	Isoproterenol (Isoprenaline)
3.	Endotoxins
4.	Bronchodilator Agents (Bronchodilators)
5.	Antigens
6.	Antigen-Antibody Complex (Immune Complex)
7.	purine