BOF 4272

Also Known As:

BOF-4272; sodium-8-(3-methoxy-4-phenylsulfinylphenyl)pyrazolo (1,5-a)-1,3,5-triazine-4-olate monohydrate; Pyrazolo(1,5-a)-1,3,5-triazin-4(1H)-one, 8-(3-methoxy-4-(phenylsulfinyl)phenyl)-, sodium salt (1:1)

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Triazines: 306
    - BOF 4272: 9

Experts

1.	Naito, S: 2 articles (06/2002 - 12/2001)
2.	Nishimura, M: 2 articles (06/2002 - 12/2001)
3.	Fukuda, Jun: 1 article (02/2002)
4.	Kawamura, Kazuhiro: 1 article (02/2002)
5.	Kodama, Hideya: 1 article (02/2002)
6.	Kumagai, Akiko: 1 article (02/2002)
7.	Kumagai, Jin: 1 article (02/2002)
8.	Sato, Naoki: 1 article (02/2002)
9.	Tanaka, Toshinobu: 1 article (02/2002)
10.	Tanikawa, Hideo: 1 article (02/2002)

Related Diseases

1.	Hyperuricemia 12/01/2001 - "The transport mechanisms of the enantiomers of BOF-4272, a new drug for the treatment of hyperuricemia, were studied using freshly prepared rat hepatocytes. " 06/01/2002 - "1. BOF-4272 (a pyrazolotriazine sulfoxide) is a new drug for the treatment of hyperuricemia. " 12/01/1999 - "BOF-4272, (+/-)-8-(3-methoxy-4- phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one, is a new drug intended for the treatment of hyperuricemia. " 07/01/1999 - "BOF-4272, (+/-)-8-(3-methoxy-4-phenylsulfinylphenyl) pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one), is a new drug intended for the treatment of hyperuricemia. " 07/01/1995 - "The effect of temperature on the local hepatic disposition of BOF-4272 [(+/-)-8-(3-methoxy-4-phenylsulfinyl-phenyl)pyrazolo[1,5-a]-1,3,5- triazine-4-olate], a new drug used to treat hyperuricemia, was investigated by means of a perfusion experiment following the pulse input into the portal vein of rat, in which the temperature of the perfusate was changed from 37 degrees C down to 4 degrees C. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/1994 - "The decrease in mitochondrial membrane potential was > 20 mV in all portions of the lobules at 60 min. The onset of hydroperoxide formation was observed at 40 min in the marginally oxygenated proximal portion of anoxic pericentral regions and the oxidative impact reached a maximum level at 60 min. Sodium (-)-8-(3-methoxy-4-phenylsulfinylphenyl) pyrazo [1,5-a]-1,3,5-triazine-4-olate monohydrate (BOF 4272), a novel xanthine oxidase inhibitor, suppressed the zone-specific oxidative changes without attenuating the increase in pyridine nucleotide autofluorescence and mitochondrial dysfunction. "
3.	Reperfusion Injury 12/01/1998 - "We investigated the effects of the xanthine oxidase inhibitor, BOF-4272, on the production of cytokine-induced neutrophil chemoattractant (CINC) following reperfusion injury in rat liver. "
4.	Cryptorchidism (Undescended Testes) 02/01/2002 - "Another highly specific xanthine oxidase inhibitor, BOF-4272, also attenuated cryptorchidism-induced testis regression. "
5.	Hypoxia (Hypoxemia) 01/01/2002 - "This examination was done in two experimental models: Cu/Zn-SOD transgenic (Tg) mice that underwent hypoxia-reoxygenation in vitro and normal mice pretreated with a specific inhibitor of xanthine oxidase, BOF-4272, followed by in vitro hypoxia-reoxygenation. "

Related Drugs and Biologics

1.	Xanthine Oxidase
2.	Triazines
3.	Cytokines
4.	Sodium
5.	Nucleotides
6.	Hydrogen Peroxide (Hydroperoxide)
7.	Chemotactic Factors
8.	pyridine
9.	sulfoxide