3- (cis- 2,6- dimethylpiperidino)sydnonimine

structure given in first source; an exogenous source of nitric oxide

Also Known As:

C 3754; C 87-3754; C-3754; C-87-3754; C87-3754; CAS-754; Sydnone imine, 3-(2,6-dimethyl-1-piperidinyl)-, cis-

Networked: 5 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        Sydnones: 2
        3-(cis-2,6-dimethylpiperidino)sydnonimine: 5

Related Diseases

1.	Shock 01/01/1993 - "In the first case, C87-3754, but not C88-3934, attenuated myocardial necrosis, and in the second case, the NO donor improved survival and moderated the indices of shock. " 11/01/1992 - "Moreover, C87-3754 attenuated the SAO shock induced decline in release of endothelium-derived relaxing factor (EDRF) from isolated superior mesenteric artery (SMA) rings stimulated by acetylcholine and A23187. "
2.	Ventricular Fibrillation 04/01/1997 - "The nitric oxide donor C87-3754 (1 mg/kg) caused a significant reduction in arterial blood pressure before coronary artery ligation but did not influence the incidence or severity of ventricular arrhythmias during a 30-min period of myocardial ischaemia [60 and 58% incidence of ventricular fibrillation (VF) in control and treated rats, respectively]. "
3.	Necrosis 01/01/1993 - "In the first case, C87-3754, but not C88-3934, attenuated myocardial necrosis, and in the second case, the NO donor improved survival and moderated the indices of shock. "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 02/01/1992 - "Our studies show that SIN-1 and C87-3754 exert beneficial effects in a 6-h model of myocardial ischemia-reperfusion. "
5.	Leukopenia 09/01/1996 - "Administration of the NO donor C87-3754 (0.75 mg kg-1 h-1, beginning 1 min after the onset of reperfusion) slightly increased survival time and reduced MPO activity and leukopenia, but did not change survival rate and mean arterial blood pressure. " 09/01/1996 - "In fact, co-administration of Ethyl-TU plus C87-3754 completely prevented mortality, reduced MPO activity, attenuated leukopenia and the profound hypotension and restored the impaired responsiveness of aortic rings to PE and ACh. "

Related Drugs and Biologics

1.	Nitric Oxide Donors
2.	Endothelium-Dependent Relaxing Factors (Endothelium Derived Relaxing Factor)
3.	Acetylcholine (Acetylcholine Chloride)
4.	Calcimycin (A23187)

Related Therapies and Procedures

1.	Ligation