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declopramide
structure in first source
Also Known As:
3-chloroprocainamide
Networked:
5
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Benzamides: 115
Procainamide: 1129
declopramide: 5
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzoates: 426
Benzamides: 115
Procainamide: 1129
declopramide: 5
Aminobenzoates: 1
para-Aminobenzoates: 43
Procainamide: 1129
declopramide: 5
Carboxylic Acids: 973
Carbocyclic Acids
Benzoates: 426
Benzamides: 115
Procainamide: 1129
declopramide: 5
Aminobenzoates: 1
para-Aminobenzoates: 43
Procainamide: 1129
declopramide: 5
Experts
1.
Leanderson, T
: 1 article (03/2002)
2.
Lindgren, H
: 1 article (03/2002)
3.
Olsson, A R
: 1 article (03/2002)
4.
Pero, R W
: 1 article (03/2002)
Related Diseases
1.
Neoplasms (Cancer)
01/01/1999 - "
It had a greater antitumor activity in vitro in HL60 or K562 cells and a similar efficacy of inhibiting tumor growth in vivo, when compared with declopramide.
"
01/01/1999 - "
However, declopramide was shown in vitro to possess a higher tumor cell absorption rate.
"
01/01/1999 - "
declopramide administered orally at 40 mg/kg gave the same efficacy of inhibiting tumor growth as im injection although oral administration had a lower bioavailability due to the formulation of N-acetyl-declopramide.
"
01/01/1999 - "
The data have shown that N-acetyl-declopramide inhibited tumor cell growth in vitro in HL60 and K562 cells, and in vivo in scid mice xenografted with a human brain astrocytoma (T24), which was evaluated after oral doses of 20 and 40 mg/kg given at 0, 24 and 48 hr +/- a single im dose of cisplatin (7.5 mg/kg).
"
01/01/1997 - "
3-Chloroprocainamide (3-CPA), an analog of metoclopramide (MCA), dose-dependently inhibited tumor growth in scid mice xenografted with a human brain astrocytoma (T24) when given intramuscularly to mice every third day for 14-20 days.
"
2.
Astrocytoma (Pilocytic Astrocytoma)
01/01/1999 - "
The data have shown that N-acetyl-declopramide inhibited tumor cell growth in vitro in HL60 and K562 cells, and in vivo in scid mice xenografted with a human brain astrocytoma (T24), which was evaluated after oral doses of 20 and 40 mg/kg given at 0, 24 and 48 hr +/- a single im dose of cisplatin (7.5 mg/kg).
"
01/01/1997 - "
3-Chloroprocainamide (3-CPA), an analog of metoclopramide (MCA), dose-dependently inhibited tumor growth in scid mice xenografted with a human brain astrocytoma (T24) when given intramuscularly to mice every third day for 14-20 days.
"
3.
Vomiting
01/01/1999 - "
Declopramide bound with affinity to 5-hydroxytryptamine3 receptors which are important in controlling vomiting.
"
4.
Edema (Dropsy)
03/01/1999 - "
Our data have shown that nicotinamide and two N-substituted benzamides, metoclopramide (MCA) and 3-chloroprocainamide (3-CPA), gave dose dependent inhibition of lipopolysacharide induced TNFalpha in the mouse within the dose range of 10-500 mg/kg. Moreover, lung edema was prevented in the rat by 3 x 50 mg/kg doses of 3-CPA or MCA, and 100-200 microM doses of MCA could also inhibit NF-kappaB in Hela cells.
"
Related Drugs and Biologics
1.
Metoclopramide (Reglan)
2.
Caspase 9
3.
Cytochromes c (Cytochrome c)
4.
NF-kappa B (NF-kB)
5.
Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.
Niacinamide (Nicotinamide)
7.
Cisplatin (Platino)
8.
Benzamides
9.
X 50
Related Therapies and Procedures
1.
Oral Administration