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2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester
Also Known As:
SDZ 205,557; SDZ 205-557; SDZ 205557; SDZ-205-557; SDZ-205557
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzoates: 426
Aminobenzoates: 1
para-Aminobenzoates: 43
2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester: 4
Carboxylic Acids: 973
Carbocyclic Acids
Benzoates: 426
Aminobenzoates: 1
para-Aminobenzoates: 43
2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester: 4
Related Diseases
1.
Pain (Aches)
03/30/1998 - "
A hypoalgesic effect of SDZ 205-557 on cutaneous pain was found at 0.1 and 1 mg/kg doses, as revealed through an enhanced nociceptive threshold in rats placed on the hotplate.
"
03/30/1998 - "
The objective of this study was to establish the activity profile of SDZ 205-557, a 5-HT4 antagonist, on cutaneous (hotplate) and visceral (writhing) models of pain, after peripheral administration.
"
2.
Tachycardia (Tachyarrhythmias)
02/01/1993 - "
In the anaesthetized, vagotomized micropig, SDZ 205,557 produced only a transient blockade of 5-HT4-mediated tachycardia.
"
11/01/1993 - "
GR1 13808 (([1-[2-[methylsulphonyl amino]ethyl]-4-piperidinyl]methyl 1-methyl-1H-indole-3-carboxylate) and SDZ 205-557 ((2-diethylaminoethyl)2-methoxy-4-amino-5-chloro-benzoate) also antagonized 5-HT-induced tachycardia but not by simple competitive blockade.6. The sinoatrial 5-HT4 receptor in the piglet has a pharmacological profile that correlates well with 5-HT4 receptors characterized in rat oesophagus, guinea-pig ileum and colon, mouse embryonic colliculi neurones and human atrium.
"
3.
Hyperglycemia
04/04/1997 - "
5-Methoxytryptamine induced a significant hyperglycemia above the dosage of 1 mg/kg. 5-Methoxytryptamine-induced hyperglycemia was antagonized by pretreatment with the 5-HT1 and 5-HT2 receptor antagonist, methysergide, or the 5-HT2A receptor antagonist, ketanserin, whereas the 5-HT3 and 5-HT4 receptor antagonist, tropisetron, and the 5-HT4 receptor antagonist, SDZ 205-557 (2-methoxy-4-amino-5-chloro-benzoic acid 2-(diethylamino) ethyl ester), showed no effect.
"
Related Drugs and Biologics
1.
Serotonin 5-HT4 Receptor Antagonists
2.
5-HT4 Serotonin Receptors
3.
5-HT2A Serotonin Receptor (5 HT2A Receptor)
4.
Methysergide (Sansert)
5.
5-Methoxytryptamine (5 Methoxytryptamine)
6.
Ketanserin
7.
Benzoates (Benzoate)
8.
Tropisetron (Navoban)
9.
indole