HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

NLA 1

structure given in first source

Also Known As:

NLA-1; 9-Acridinamine, N-(3-(2-nitro-1H-imidazol-1-yl)propyl)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Nitroimidazoles: 565
        NLA 1: 2
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - Aminoacridines: 3
        NLA 1: 2
Organic Chemicals: 133
- Nitro Compounds: 66
  - Nitroimidazoles: 565
    - NLA 1: 2

Related Diseases

1.	Neoplasms (Cancer) 01/01/1992 - "NLA-1 lacks radiosensitizing activity against SCCVII or EMT6 tumors in vivo at the maximum tolerated dose (MTD) of 100 mumol.kg-1."
2.	Hypoxia (Hypoxemia) 01/01/1994 - "THNLA-1 is a good hypoxia-selective cytotoxin with a differential toxicity of approximately equal to 11 in V79 cells, but it is approximately equal to 2 times less potent on a concentration basis than NLA-1 (the 2-nitroimidazole linked acridine analog). "

Related Drugs and Biologics

1.	Nitroimidazoles
2.	Cytotoxins (Cytolysins)
3.	Acridines
4.	9- (3- (2- nitro- 1- imidazolyl)propylamino)- 1,2,3,4- tetrahydroacridine