Mycobacterium tuberculosis antigens

contains 144 amino acids; MW 16.277 kDa; 16 kDa protein was previously referred to as 14 kDa protein; aa sequence given in first source

Also Known As:

14K antigen, Mycobacterium tuberculosis; 16 kDa alpha-crystallin antigen, Mycobacterium tuberculosis; 16K antigen, M. tuberculosis; 16K protein, M. tuberculosis; MT 14 k antigen; Mycobacterium tuberculosis 14K antigen

Networked: 125 relevant articles (4 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ottenhoff, Tom H M: 11 articles (06/2021 - 08/2009)
2.	Singh, Mahavir: 7 articles (01/2022 - 12/2006)
3.	Walzl, Gerhard: 5 articles (01/2022 - 08/2009)
4.	Franken, Kees L M C: 5 articles (06/2021 - 08/2009)
5.	Chegou, Novel N: 4 articles (01/2022 - 01/2013)
6.	van Meijgaarden, Krista E: 4 articles (01/2020 - 01/2011)
7.	Boom, W Henry: 4 articles (01/2017 - 01/2008)
8.	Black, Gillian F: 4 articles (01/2015 - 08/2009)
9.	Baumann, Ralf: 3 articles (01/2022 - 12/2014)
10.	Kaempfer, Susanne: 3 articles (01/2022 - 12/2014)

Related Diseases

1.	Pulmonary Tuberculosis 09/23/2013 - "In this study, we investigated the protective efficacy of 16 different novel Mycobacterium tuberculosis antigens using an aerogenic mouse model of pulmonary tuberculosis. " 01/01/1991 - "Study of immunologic reactivity in patients with disseminated pulmonary tuberculosis has demonstrated that 80% of patients have sensitization to Mycobacterium tuberculosis antigens, in addition to that to bacterial flora (Streptococcus, Staphylococcus, Pneumococcus). " 11/14/2023 - "Quantitation of Circulating Mycobacterium tuberculosis Antigens by Nanopore Biosensing in Children Evaluated for Pulmonary Tuberculosis in South Africa." 01/01/2017 - "Comparison of the Performance of Urinary Mycobacterium tuberculosis Antigens Cocktail (ESAT6, CFP10, and MPT64) with Culture and Microscopy in Pulmonary Tuberculosis Patients." 12/01/2012 - "Analysis of immune responses against a wide range of Mycobacterium tuberculosis antigens in patients with active pulmonary tuberculosis."
2.	Tuberculosis (Tuberculoses) 01/14/2014 - "Recognition of Mycobacterium tuberculosis antigens by T lymphocytes is known to be important for immune protection against tuberculosis, but it is unclear whether human T cell recognition drives antigenic variation in M. " 07/01/2017 - "In this review, we have made an attempt to combine current studies on the usefulness of the multi-component Mycobacterium tuberculosis antigens in serological tests for the diagnosis of tuberculosis." 01/01/2022 - " tuberculosis is usually the result of hematogenous dissemination or spread from underlying foci and it must be distinguished from tuberculids, resulting from the immunological reaction to Mycobacterium tuberculosis antigens. " 01/01/2022 - "To elucidate which HLA class II allotypes in an individual are preferentially used in tuberculosis, CD4+ T cells specific to TB10.4, Ag85b, ESAT-6, and CFP-10 of Mycobacterium tuberculosis antigens were analyzed comprehensively. " 01/01/2021 - "HIV-Infected Patients Developing Tuberculosis Disease Show Early Changes in the Immune Response to Novel Mycobacterium tuberculosis Antigens."
3.	Infections 12/09/2022 - "The tests for TB infection have limitations and diagnosis still relies on an indirect immunological assessment of cellular immune response to Mycobacterium tuberculosis antigens using immunodiagnostic testing. " 06/03/2021 - "In-vivo expressed Mycobacterium tuberculosis antigens recognised in three mouse strains after infection and BCG vaccination." 10/01/2018 - "Genome wide approaches discover novel Mycobacterium tuberculosis antigens as correlates of infection, disease, immunity and targets for vaccination." 01/01/2000 - "Individuals sensitised to Mycobacterium tuberculosis antigens by infection, vaccination or Mantoux test generate specific memory cells. " 01/01/2000 - "Individuals sensitised to Mycobacterium tuberculosis antigens by infection, vaccination or Mantoux test generate specific memory cells. "
4.	Latent Tuberculosis 07/01/2023 - "Latent tuberculosis is defined as a state of persistent immune response stimulated by Mycobacterium tuberculosis antigens with no evidence and signs of active TB . " 09/01/2021 - "The latent tuberculosis infection (LTBI) is a state of persistent immune response to stimulation by Mycobacterium Tuberculosis antigens without clinical manifestation: the healthcare workers (HCWs) have a higher exposure risk so prevention is an important challenge for occupational medicine. " 10/01/2015 - "To exclude latent tuberculosis, an assay specific for Mycobacterium tuberculosis antigens was performed, with a negative result. " 02/01/2006 - "Effect of treatment of latent tuberculosis infection on the T cell response to Mycobacterium tuberculosis antigens." 11/01/2020 - "However, these studies ignore an important fact: according to World Health Organization estimates, about a quarter of the world's population may have latent tuberculosis infection (LTBI), a condition in which there is no evidence of clinically active tuberculosis but persistent immune responses are stimulated by Mycobacterium tuberculosis antigens. "
5.	HIV Infections (HIV Infection) 01/01/2013 - "Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa." 11/01/2012 - "Tuberculosis after commencing antiretroviral therapy for HIV infection is associated with elevated CXCL9 and CXCL10 responses to Mycobacterium tuberculosis antigens."

Related Drugs and Biologics

1.	Mitogens
2.	HLA-DR Antigens (HLA-DR)
3.	Antibodies
4.	Antigens
5.	Immunoglobulin G (IgG)
6.	Immunoglobulin A (IgA)
7.	DNA Vaccines
8.	Interleukin-15 (Interleukin 15)
9.	Epitopes
10.	Cytokines

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics