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SDZ 280 446
a potent P-glycoprotein inhibitor; structure given in first source; empirical formula C61H99N9O14, MW 1182.6
Also Known As:
SDZ 280-446; SDZ-280 446; SDZ-280446; cyclo-(Pec1-MeVal2-Val3-(-O-t.Bu-MeAsp4)-Melle5-Melle6-Gly7-MeVal8-(O-Me-Tyr)-L-Hpa10)
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Cyclic Peptides: 530
SDZ 280 446: 4
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Cyclic Peptides: 530
SDZ 280 446: 4
Related Diseases
1.
Neoplasms (Cancer)
10/09/1995 - "
SDZ PSC 833 or SDZ 280-446 are strong blockers of the function of class I mdr gene-encoded P-glycoprotein molecules, which were developed for the reversal of multi-drug-resistance of tumor cells.
"
12/01/1993 - "
These MDR-CEM cells displayed virtually no chemosensitization by 1 microM verapamil or 1 microgram/ml (about 0.8 microM) CsA, whereas their chemosensitization for different anti-cancer drugs (ACD) was rather stable (from 51- to 82-fold) with 1 microgram/ml (about 0.8 microM) SDZ 280-446, while being very unbalanced (from 5- to 38-fold) with 1 microgram/ml (about 0.8 microM) SDZ PSC 833.
"
03/17/1993 - "
The combination of taxol with SDZ PSC 833 or SDZ 280-446 may be recommended for treatment of multidrug-resistant cancers.
"
03/17/1993 - "
SDZ PSC 833 and SDZ 280-446 can restore the normal taxol sensitivity of highly resistant multidrug-resistant tumor cells.
"
03/17/1993 - "
At nontoxic concentrations (0.3-1 microM), SDZ PSC 833 and SDZ 280-446 produced an almost complete reversal of the high taxol resistance of the multidrug-resistant tumor cells, whereas only partial restoration of sensitivity to taxol was achieved with verapamil.
"
2.
Multiple Myeloma
04/01/1998 - "
Cyclosporin A (CsA), CsG, PSC 833 or SDZ 280-446, and primary CsA and CsG metabolites, were tested for their ability to inhibit drug transport mechanisms of ex vivo malignant B cells from 81 patients with multiple myeloma as compared to B cells from normal donors, as measured by the export of the dye rhodamine 123 (Rh123) using multiparameter flow cytometry.
"
Related Drugs and Biologics
1.
valspodar (PSC 833)
2.
Verapamil (Calan)
3.
Member 1 Subfamily B ATP Binding Cassette Transporter
4.
Rhodamine 123
5.
Paclitaxel (Taxol)
6.
Cyclosporine (Ciclosporin)
7.
Coloring Agents (Dyes)