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isoserine

RN given refers to cpd without isomeric designation

Also Known As:

2-hydroxy-3-aminopropanoic acid; isoserine, (+-)-isomer; isoserine, (R)-isomer; isoserine, (S)-isomer

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Neutral Amino Acids: 200
    - Serine: 6037
      - isoserine: 4

Experts

1.	Clarkson, Andrew N: 1 article (01/2019)
2.	Dalby, Nils Ole: 1 article (01/2019)
3.	Gowing, Emma K: 1 article (01/2019)
4.	Johansen, Nina B: 1 article (01/2019)
5.	Lie, Maria Ek: 1 article (01/2019)
6.	Thiesen, Louise: 1 article (01/2019)
7.	Wellendorph, Petrine: 1 article (01/2019)
8.	Chattopadhyay, Sunil K: 1 article (07/2008)
9.	Darokar, Mahendra P: 1 article (07/2008)
10.	Faridi, Uzma: 1 article (07/2008)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1999 - "This review describes recent advances in the chemistry of isoserines and taxoid anticancer agents at the biomedical interface including (i) the development of highly efficient method for the synthesis of isoserine side chains of taxoids and (ii) the synthesis and structure-activity relationship (SAR) study of taxoids featuring discovery and development of the "second generation" taxoid anticancer agents that possess exceptional activities against drug-resistant cancer cells." 08/18/2003 - "In the course of our investigation into the use of taxol as a lead compound to design new molecules with anti-cancer activity, we have synthesized four compounds based on protected guanosine coupled to taxol isoserine side-chain analogues. "
2.	Stroke (Strokes) 01/01/2019 - "Therefore, we aimed to assess whether the GAT3 substrate, L-isoserine, could increase post-stroke functional recovery. " 01/01/2019 - "L-Isoserine (38 µM or 380 µM) administered directly into the infarct from day 5 to 32 post-stroke, significantly increased motor performance in the grid-walking and cylinder tasks in a concentration-dependent manner, without affecting infarct volumes. "
3.	Liver Neoplasms (Liver Cancer) 07/01/2008 - "Out of the seven analogues synthesized, C-13 oxidized brevifoliol-5-[N-tert-butoxycarbonyl amino-(2'R,3'S)-3'-phenyl isoserine] analogue was interesting as it exhibited selective and potent cytotoxicity against liver cancer cell line predominantly."
4.	Infarction (Infarctions) 01/01/2019 - "Additionally, L-isoserine induced a lasting increase in GAT3 expression in peri-infarct regions accompanied by a small decrease in GFAP expression. " 01/01/2019 - "L-Isoserine (38 µM or 380 µM) administered directly into the infarct from day 5 to 32 post-stroke, significantly increased motor performance in the grid-walking and cylinder tasks in a concentration-dependent manner, without affecting infarct volumes. "
5.	Ischemic Stroke 01/01/2019 - "GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice."

Related Drugs and Biologics

1.	Taxoids (Taxanes)
2.	Antineoplastic Agents (Antineoplastics)
3.	Paclitaxel (Taxol)
4.	Guanosine
5.	brevifoliol