E 4080

Also Known As:

E-N-(3-((N'-(2-(3,5-dimethoxyphenyl)ethyl)-N'-methyl)amino)propyl)-4-(4-(1H-imidazol-1-yl)phenyl)-3-butenamide dihydrochloride dihydrate; E4080

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

1.	Angina Pectoris 01/01/1994 - "These results suggest that E4080 exerts actions on the cardiovascular system which may be useful in the treatment of angina pectoris."
2.	Bradycardia 12/01/1991 - "Ionic currents involved in vasodilating actions of E4080, a newly synthesized bradycardia-inducing agent, in dispersed smooth muscle cells of the rabbit portal vein." 10/22/1991 - "On administration in sinus node artery, E4080 (10 and 30 micrograms) selectively decreased HR. Glibenclamide, an ATP-sensitive K+ channel blocker (5 mg/kg i.v.), inhibited both the increase in CBF and the decrease in MAP caused by E4080 (1 mg/kg i.v.) but did not inhibit the bradycardia. "
3.	Tachycardia (Tachyarrhythmias) 01/01/1994 - "It is concluded that E4080 produces coronary and peripheral vasodilation, without inducing a reflex tachycardia despite sympathetic neural activation. "