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trefoil factor

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member of trefoil peptide family; from rat intestinal villus epithelial cells; has homology with (pancreatic) porcine, mouse & human trefoil peptides; 81 amino acid residues; amino acid sequence in first source; RefSeq NM_053844 (rat), NM_005423 (human); do not confuse with SML1 protein

Also Known As:

ITF protein; SP, rat gastrointestinal tract; TFF2 protein; TFF2 protein, human; Tff2 protein, rat; human SML1/hSP; human spasmolytic protein SML1; human spasmolytic protein hSP/SML1; intestinal trefoil factor; spasmolytic polypeptide, rat; spasmolytic polypeptide, rat gastric mucous cells; spasmolytic protein 1, rat; trefoil factor 2 (spasmolytic protein 1), human; trefoil factor 2, rat

Networked: 284 relevant articles (10 outcomes, 35 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Peptides: 22950
  - trefoil factor: 284

Experts

1.	Zhang, Yun: 8 articles (01/2015 - 05/2005)
2.	Westley, Bruce R: 7 articles (08/2011 - 01/2003)
3.	May, Felicity E B: 7 articles (03/2009 - 01/2003)
4.	Wang, Timothy C: 6 articles (03/2012 - 08/2004)
5.	Takano, Toru: 6 articles (02/2012 - 01/2004)
6.	Thim, Lars: 5 articles (07/2015 - 01/2003)
7.	Zhang, Yong: 5 articles (01/2015 - 05/2005)
8.	Sun, Yong: 5 articles (01/2013 - 07/2008)
9.	Peng, Xi: 5 articles (01/2013 - 07/2008)
10.	Giraud, Andrew S: 5 articles (12/2012 - 11/2002)

Related Diseases

1.	Colitis 08/01/2006 - "Trefoil factor (TFF) producer strains have also been shown to be very effective in the treatment of acute colitis. " 01/01/2005 - "In order to investigate the protective effects of intestinal trefoil factor (ITF) on colonic mucosa in experimental colitis of rats, ITF was detected by RT-PCR and immunohistochemistry at different time points. " 10/01/2011 - "Effects of recombinant human intestinal trefoil factor on trinitrobenzene sulphonic acid induced colitis in rats." 01/01/2005 - "Effects of intestinal trefoil, factor on colonic mucosa in experimental colitis of rats." 10/01/2004 - "Furthermore, colons with constitutive activation of HIF displayed increased expression levels of HIF-1-regulated barrier-protective genes (multidrug resistance gene-1, intestinal trefoil factor, CD73), resulting in attenuated loss of barrier during colitis in vivo. "
2.	Wounds and Injuries (Trauma) 10/01/2006 - "[Protective effects of recombinant intestinal trefoil factor against intestinal injuries induced by endotoxin in young rats]." 09/01/2011 - "Changing of trefoil factor family (1,2,3) and numbers of gastric injuries were evaluated. " 09/01/2011 - "We focused on trefoil factor family as one of defensive system for gastrointestinal injuries. " 05/01/2011 - "Trefoil factor 3 and histatin promote the process of wound closure. " 07/01/2010 - "Trefoil factor 3 (TFF3) is involved in both protecting the intestinal epithelium against injury as well as aiding in wound repair following injury. "
3.	Mucositis 03/01/2004 - "These studies suggest that intestinal trefoil factor is involved in protection against and recovery from intestinal mucositis induced by radiation and chemotherapy." 03/01/2004 - "Intestinal trefoil factor-deficient mice (intestinal trefoil factor(-/-)) were more susceptible to chemotherapy- and radiation-induced mucositis. " 03/01/2004 - "Oral recombinant intestinal trefoil factor reduced the severity of both chemotherapy-induced and chemotherapy/radiotherapy-induced intestinal mucositis. " 12/01/2011 - "Trefoil factor family peptides (TFF, trefoil peptides), present in saliva, contribute to epithelial restitution and repair and are therefore potentially important in the healing phase of mucositis. " 12/01/2011 - "Trefoil factor family peptides are increased in the saliva of children with mucositis."
4.	Colorectal Neoplasms (Colorectal Cancer) 02/01/2015 - "The value of trefoil factor 3 expression in predicting the long‑term outcome and early recurrence of colorectal cancer." 11/01/2013 - "Trefoil factor 1 gene alternations and expression in colorectal carcinomas." 12/01/1999 - "Roles of intestinal trefoil factor (ITF) in human colorectal cancer: ITF suppresses the growth of colorectal carcinoma cells." 11/01/1997 - "The aim of this work was to investigate the expression of the intestinal trefoil factor gene in human colorectal cancers. " 07/01/2013 - "Aberrant expression of trefoil factor 3 is associated with colorectal carcinoma metastasis."
5.	Necrotizing Enterocolitis 01/01/2014 - "Recombinant human trefoil factor 3 ameliorates bowel injury: its anti-inflammatory effect on experimental necrotizing enterocolitis." 01/01/2007 - "Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model." 01/01/2007 - "Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model." 11/15/2003 - "The aim of this study was to determine the effect of recombinant human trefoil factor 3 (rhTFF3) on hypoxia-induced necrotizing enterocolitis (NEC) in immature rats. " 11/15/2003 - "The therapeutic effect of recombinant human trefoil factor 3 on hypoxia-induced necrotizing enterocolitis in immature rat."

Related Drugs and Biologics

1.	trefoil factor
2.	Peptides
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Interleukin-1beta (Interleukin 1 beta)
5.	Amine Oxidase (Copper-Containing)
6.	Cyclooxygenase 2 (Cyclooxygenase-2)
7.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
8.	Dextrans (Dextran)
9.	sodium sulfate (sodium bisulfate)
10.	Mucin-3

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Sprays
3.	Radiotherapy
4.	Cell Transplantation
5.	Enema (Enemas)