4'-demethylepipodophyllotoxin

structure in first source

Also Known As:

4'-demethyl epipodophyllotoxin; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8aalpha,9beta))-

Networked: 17 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Li, Hong-Mei: 2 articles (08/2021 - 06/2014)
2.	Tang, Ya-Jie: 2 articles (08/2021 - 06/2014)
3.	Zhao, Wei: 2 articles (08/2021 - 06/2014)
4.	Arimondo, Paola B: 2 articles (07/2005 - 01/2005)
5.	Dauzonne, Daniel: 2 articles (07/2005 - 01/2005)
6.	Duca, Maria: 2 articles (07/2005 - 01/2005)
7.	Guianvarc'h, Dominique: 2 articles (07/2005 - 01/2005)
8.	Monneret, Claude: 2 articles (07/2005 - 01/2005)
9.	Duan, Ying: 1 article (08/2021)
10.	Li, Shengying: 1 article (08/2021)

Related Diseases

1.	Neoplasms (Cancer) 08/01/1978 - "The formation and elimination of the metabolite of 4'-demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside) (I) were studied in seven patients with advanced cancer who received I intravenously. " 07/01/1975 - "We evaluated the responses of 39 children with cancer who, after failure to respond to conventional chemotherapeutic agents, received either or both of two epipodophyllotoxins: 4'-demethylepipodophyllotoxin 9-(4,6-o-2-thenylidene-beta-D-glucopyranoside) (NSC-122819) and 4'-demethylepipodophyllotoxin 9-(4,6-o-ethylidene-beta-D-glucopyranoside) (NSC-141540). " 06/10/2014 - "Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways." 01/01/2013 - "A series of carbamate derivatives of 4'-demethylepipodophyllotoxin have been synthesized, and their cytotoxicities against several human cancer cell lines, including HeLa, A549, HCT-8, and HL-60 cells, evaluated. " 01/01/2008 - "High-resolution electrospray ionization multistage tandem mass spectrometry (MS 1-7) in negative ion mode was used to determine the accurate masses and fragmentation pathways of two compounds, 4'-demethylepipodophyllotoxin and 4'-demethyl-4-azido-4-deoxyepipodophyllotoxin, which are key intermediate compounds for the preparation of podophyllotoxin-type anti-cancer drugs. "
2.	Leukemia 05/01/1980 - "Partial cross-resistance of cultured murine leukemia vincristine-resistant P388 cells to 4'-demethylepipodophyllotoxin ethylidene-beta-D-glucoside." 02/01/1991 - "DNA topoisomerase inhibitors, camptothecin and 4'-demethylepipodophyllotoxin ethylidene-beta-D-glucoside (VP16) had strong differentiation-inducing activity for all five kinds of leukemia cells examined (human HL60, U937, ML1, and K562 cells and mouse M1 cells) as judged from measurements of various differentiation markers. "
3.	Carcinogenesis 06/01/1999 - "Chemopreventive effect of 4'-demethyl epipodophyllotoxin on DMBA/TPA-induced mouse skin carcinogenesis." 06/01/1999 - "The chemopreventive effect of topical application of 4'-demethyl epipodophyllotoxin (DMEP), an antimitotic agent, on a two-stage skin carcinogenesis model in Swiss Albino mice induced by 9, 10-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) was investigated. "
4.	Leukemia L1210 08/01/1978 - "Comparison of uptake and binding of two epipodophyllotoxin glucopyranosides, 4'-demethyl epipodophyllotoxin thenylidene-beta-D-glucoside and 4'-demethyl epipodophyllotoxin ethylidene-beta-D-glucoside, in the L1210 leukemia cell."
5.	Glioblastoma (Glioblastoma Multiforme) 05/01/2015 - "Solid lipid nanoparticles (SLNs) grafted with p-aminophenyl-α-D-manno-pyranoside (APMP) and folic acid (FA) (APMP-FA-SLNs) were applied to encapsulate 4'-demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside) (etoposide) (ETP) for promoting the antiproliferation of malignant glioblastoma multiforme. "

Related Drugs and Biologics

1.	Etoposide (VP 16)
2.	Podophyllotoxin (Condylox)
3.	Glucosides
4.	Vincristine (Oncovin)
5.	Poisons
6.	Topoisomerase II Inhibitors
7.	Topoisomerase Inhibitors
8.	Antimitotic Agents
9.	Tubulin
10.	Triazoles

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Combination Drug Therapy (Combination Chemotherapy)