U 78518F

a member of the lazaroid family of 21-amino steroid derivatives; RN given is for HCl

Also Known As:

2H-1-benzopyran-6-ol,2-((4-(3-(ethylamino)-2-pyridinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,5,7,8-tetramethyl-(Z)-2-butenedioate; U 78518E; U-78518E; U-78518F; U78518F

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - U 78518F: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - U 78518F: 3
  - Piperazines: 26
    - U 78518F: 3

Related Diseases

1.	Acute Lung Injury 05/01/1993 - "We examined the effect of intravenous U-78518F on acute lung injury in septic guinea pigs over 8 h. " 05/01/1993 - "Attenuation of acute lung injury and oxygen radical production by the 21-aminosteroid, U-78518F."
2.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 04/01/1993 - "We examined the effects of a potent antioxidant compound, U78518F, on the incidence of diabetes and pancreatic islet infiltration with lymphocytes and monocytes (insulitis) in the non-obese diabetic (NOD) mouse, an animal model for human IDDM. "
3.	Breast Neoplasms (Breast Cancer) 05/30/1992 - "The antiproliferative properties of three 21-aminosteroid antioxidants (lazaroids), 21-[4-[5,6-bis(diethylamino)-2-pyridinyl]-1- piperazinyl]-16 alpha-methylpregna-1,4,9(11)triene-3,20-dione, hydrochloride (U74500A), 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piper- azinyl]-pregna-1,4,9(11)-triene-3,20-dione, monomethanesulfonate (U74389F), 2H-1-benzopyran-6-ol, 2-[[4-[3-(ethylamino)-2-pyridinyl]-1-piperzinyl]methyl]-3,4- dihydro-2,5,7,8-tetramethyl-, (Z)-2-buten dioate (U78518F), on human breast cancer cells are described. "

Related Drugs and Biologics

1.	Antioxidants
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	U 74389F
4.	U 74500A