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phenazine di-N-oxide

used to link antisense oligonucleotides for site-specific degradation of DNA

Also Known As:

Phenazine, 5,10-dioxide

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenazines: 42
      - phenazine di-N-oxide: 3

Experts

1.	Aesoy, Reidun: 1 article (04/2021)
2.	Døskeland, Stein Ove: 1 article (04/2021)
3.	Herfindal, Lars: 1 article (04/2021)
4.	Lekve, Viola: 1 article (04/2021)
5.	Rongved, Pål: 1 article (04/2021)
6.	Støa, Sindre: 1 article (04/2021)
7.	Viktorsson, Elvar Örn: 1 article (04/2021)
8.	Cabrera, Mauricio: 1 article (09/2008)
9.	Cerecetto, Hugo: 1 article (09/2008)
10.	González, Mercedes: 1 article (09/2008)

Related Diseases

1.	Hypoxia (Hypoxemia) 09/01/2008 - "Previous studies of the phenazine 5,10-dioxide mechanism of action indicated that a bioreduction process could be involved in its selective toxicities, maybe as result of its potential H(*)-releasing capability in hypoxia. " 04/19/2021 - "We have recently demonstrated that the phenazine 5,10-dioxide natural products iodinin (3) and myxin (4) exhibit potent and hypoxia-selective cell death on MOLM-13 human AML cells, and that the N-oxide functionalities are pivotal for the cytotoxic activity. "
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/19/2021 - "New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells."
3.	Neoplasms (Cancer) 09/01/2008 - "Some derivatives of phenazine 5,10-dioxide are selectively toxic to hypoxic cells commonly found in solid tumors. "
4.	Ascites 02/01/1961 - "Effect of phenazine di-N-oxide and phenazine on total cellular dry mass of mouse Ehrlich ascites cells as measured by interference microscopy."

Related Drugs and Biologics

1.	Prodrugs
2.	Oxides
3.	iodinin
4.	myxin
5.	phenazine