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perlecan

amino acid sequence and structural model given in first source

Also Known As:

HSPG2 protein, human; Hspg2 protein, mouse; Hspg2 protein, rat; heparan sulfate proteoglycan 2; heparan sulfate proteoglycan 2 (perlecan) protein, human; heparan sulfate proteoglycan 2 protein, rat; perlecan (heparan sulfate proteoglycan 2) protein, mouse

Networked: 232 relevant articles (2 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Saku, Takashi: 10 articles (09/2014 - 08/2002)
2.	Iozzo, Renato V: 9 articles (10/2015 - 10/2003)
3.	Bix, Gregory J: 9 articles (10/2013 - 08/2011)
4.	Cheng, Jun: 8 articles (09/2014 - 02/2004)
5.	Arikawa-Hirasawa, Eri: 6 articles (08/2015 - 05/2002)
6.	Maruyama, Satoshi: 6 articles (09/2014 - 05/2008)
7.	Yamazaki, Manabu: 6 articles (09/2014 - 03/2004)
8.	Tran-Lundmark, Karin: 5 articles (07/2015 - 03/2004)
9.	Tran, Phan-Kiet: 5 articles (07/2015 - 04/2003)
10.	Hedin, Ulf: 5 articles (07/2015 - 03/2004)

Related Diseases

1.	Stroke (Strokes) 10/01/2013 - "Perlecan domain V is neuroprotective and affords functional improvement in a photothrombotic stroke model in young and aged mice." 01/01/2014 - "Key to its appeal is that perlecan DV is endogenously and persistently generated in the brain after stroke and has significant angio-modulatory properties. " 03/20/2013 - "In this review, I will discuss the evidence that suggests that perlecan domain V may be just that substance, a potential beacon of hope for stroke patients." 03/20/2013 - "Perlecan domain V therapy for stroke: a beacon of hope?" 01/01/2012 - "This mini-review will discuss beneficial roles of perlecan protein fragment generation within the brain during stroke."
2.	Albuminuria 11/01/2001 - "Decreased perlecan in the glomerular basement membrane has a central role in the development of diabetic albuminuria. " 01/01/2013 - "Sulodexide treatment significantly reduced albuminuria, improved renal function, increased glomerular perlecan expression and reduced collagen type I and IV expression and ERK activation. " 01/01/2013 - "Mice with DN showed progressive albuminuria and renal deterioration over time, accompanied by mesangial expansion, PKC and ERK activation, increased renal expression of TGF-β1, fibronectin and collagen type I, III and IV, but decreased glomerular perlecan expression. " 09/01/1994 - "At 12 months albuminuria, renal collagen IV and perlecan mRNA levels, anionic and neutral dextran clearances, glomerular basement membrane morphometry, and mesangial cell proliferation were evaluated. " 02/01/2007 - "In summary, the differential effects of PKC-beta deficiency on diabetes-induced renal hypertrophy and albuminuria suggest that PKC-beta contributes to high-glucose-induced TGF-beta1 expression and renal fibrosis, whereas perlecan, as well as nephrin, expression and albuminuria is regulated by other signaling pathways."
3.	Carcinoma (Carcinomatosis) 01/01/2013 - "The aim of our study was to understand the immuno-localization of perlecan in oral dysplastic epithelium and oral carcinomas. " 01/01/2006 - "To study the expression of perlecan in human laryngeal carcinoma cells and its significance. " 12/01/2001 - "Three cellular sources of perlecan were examined in this study, namely human umbilical arterial endothelial cells (HUAEC), a transformed human umbilical venous endothelial cell line (C 1 1 STH) and a human colon carcinoma cell line (WiDr). " 06/01/2001 - "Therefore, this study first established lines of P19 mouse embryonic carcinoma cells stably carrying an expression vector encoding the complete perlecan core protein (approximately 400 kD). " 09/01/2014 - "The three-dimensional (3D) reconstruction demonstrated three kinds of perlecan profiles for inside (I) and outside (O) areas of the carcinoma cell focus: mode 1, I(+)/O(-) ; mode 2, I(+)/O(+) ; and mode 3, I(-)/O(+). "
4.	Amyloid Plaque 10/01/1997 - "These studies have identified microglia/macrophages as one potential source of perlecan (or a perlecan-related macromolecule) which may be important for the ongoing accumulation of both perlecan and A beta in the amyloid deposits of AD." 09/01/1996 - "These results therefore suggest that perlecan persistence in A beta-amyloid deposits in late-stage AD may be primarily due to decreased perlecan degradation and removal." 06/20/1995 - "In the present investigation, the differential binding of previously characterized endothelial cell (EC)- and smooth muscle cell (SMC)-derived PGs to A beta was examined to determine whether the accumulation of A beta in cerebrovascular amyloid deposits may be due to its interactions with perlecan. " 01/03/2000 - "Following infusion of A beta + perlecan, the glial cells segregated in a manner similar to that associated with compacted amyloid plaques in Alzheimer's disease (AD). " 07/20/1998 - "It is also possible that a similar increased expression of perlecan in neurons and reactive astrocytes could occur in humans following neuronal injury, which could be a source of perlecan, in senile plaques of Alzheimer's disease."
5.	Alzheimer Disease (Alzheimer's Disease) 12/04/2003 - "A genetic association of an intronic single nucleotide polymorphism site of heparan sulfate proteoglycan 2 (HSPG2) with Alzheimer's disease (AD) was investigated among Finnish AD patients (n=213) and controls (n=269). " 12/04/2003 - "Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathology." 01/03/2000 - "Following infusion of A beta + perlecan, the glial cells segregated in a manner similar to that associated with compacted amyloid plaques in Alzheimer's disease (AD). " 07/20/1998 - "It is also possible that a similar increased expression of perlecan in neurons and reactive astrocytes could occur in humans following neuronal injury, which could be a source of perlecan, in senile plaques of Alzheimer's disease." 07/01/2004 - "An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, HSPG2) and Alzheimer's disease."

Related Drugs and Biologics

1.	glucuronyl glucosamine glycan sulfate (Vessel)
2.	Collagen Type I (Type I Collagen)
3.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
4.	Collagen
5.	Fibronectins (Fibronectin)
6.	Versicans (Versican)
7.	Amyloid (Amyloid Fibrils)
8.	Proteoglycans (Proteoglycan)
9.	Heparitin Sulfate (Heparan Sulfate)
10.	Laminin (Merosin)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Stents
3.	Homologous Transplantation (Allograft)
4.	Catheters
5.	Carotid Endarterectomy