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U46,195

stimulates the production of tissue-type plasminogen activator; structure in second source; PAF antagonist

Also Known As:

U 46195; U-46,195; U-46195

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - U46,195: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        U46,195: 1

Related Diseases

1.

Thrombosis (Thrombus)

12/01/1991 - "In contrast, in dogs given saline solution, reocclusion occurred in eight of eight (p = 0.007 compared with U46,195) and five of eight arteries by platelet-rich and fibrin-rich thrombosis, respectively. "
12/01/1991 - "After thrombosis, administration of U46,195 before thrombolysis was induced with human recombinant tissue-type plasminogen activator (1.7 mg/kg intravenously over 60 min) prevented reocclusion within 120 min in six of eight and six of seven arteries by platelet-rich and fibrin-rich thrombosis, respectively. "

Related Drugs and Biologics

1.	Tissue Plasminogen Activator (Alteplase)
2.	Fibrin
3.	Saline Solution