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remifentanil (Ultiva)

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PA refers to mono-HCl; structure in first source

Also Known As:

Ultiva; 3-(4-methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic acid methyl ester; Abbott brand of remifentanil; GI 87084B; GI-87084B; GI87084B; Glaxo Wellcome brand of remifentanil; GlaxoSmithKline brand of remifentanil; remifentanil hydrochloride; remifentanil monohydrochloride; 1-Piperidinepropanoic acid, 4-(methoxy-carbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester

Networked: 1239 relevant articles (106 outcomes, 251 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Piperidines: 12
    - remifentanil: 1239

Experts

1.	Gu, Xiaoping: 8 articles (07/2015 - 01/2009)
2.	Ma, Zhengliang: 8 articles (07/2015 - 01/2009)
3.	Crawford, Mark W: 8 articles (01/2012 - 06/2005)
4.	Zhang, Wei: 7 articles (07/2015 - 03/2012)
5.	Angst, Martin S: 7 articles (06/2015 - 03/2003)
6.	Liu, Yue: 6 articles (05/2015 - 01/2009)
7.	Tobias, Joseph D: 6 articles (01/2015 - 11/2004)
8.	Puig, Margarita M: 6 articles (02/2013 - 03/2006)
9.	Cabañero, David: 6 articles (10/2012 - 03/2006)
10.	Wilhelm, W: 6 articles (04/2012 - 12/2001)

Related Diseases

1.	Pain (Aches) 05/01/2009 - "Remifentanil is safe and highly effective for pain control during percutaneous transhepatic biliary drainage. " 09/01/2012 - "The analgesic efficacy of remifentanil used for labour pain was evaluated as moderate (55%) or good (43%). " 04/01/2011 - "The decrease in pain scores in the epidural group was significantly greater than the remifentanil group at all time intervals. " 01/01/2006 - "Remifentanil infusion during HSG is superior to placebo for relief of pain with minimal opioid side effects." 05/01/2013 - "Continuous infusion of low-dose remifentanil is a safe and effective method for palliation of pain in epidural catheterization."
2.	Postoperative Pain 08/01/2000 - "Postoperative pain scores were significantly greater in the remifentanil group. " 03/01/2001 - "We conclude that IV remifentanil is an effective and safe opioid for the treatment of postoperative pain at a constant dose of 0.1 microg. " 03/01/2001 - "Our study suggests that the use of a constant continuous infusion of remifentanil 0.1 microg.kg(-1).min(-1)IV is an effective alternative in the treatment of severe postoperative pain." 09/01/2015 - "Remifentanil infusion 0.1-0.3 μg/kg/min during cardiac surgery was safe, with no exaggerated postoperative pain or opioid consumption." 09/01/2015 - "Remifentanil 0.3 μg/kg/min infusion did not increase postoperative pain or opioid consumption after cardiac surgery compared to the 0.1 μg/kg/min infusion. "
3.	Hyperalgesia 10/01/2014 - "Selective GSK-3β inhibitors, LiCl and TDZD, treatment ameliorates remifentanil-induced postoperative hyperalgesia, and this was associated with the downregulated GluR1 subunit in the membrane fraction (254 ± 23.51 vs 119 ± 14.74, P = 0.0027; 254 ± 23.51 vs 124 ± 9.35, P = 0.0032). " 01/01/2015 - "Several studies have demonstrated that intraoperative remifentanil infusions have been associated with opioid-induced hyperalgesia (OIH). " 10/01/2014 - "In this study, we demonstrated that GSK-3β inhibition prevented remifentanil-induced postoperative hyperalgesia via regulating α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) expression and function in the spinal dorsal horn. " 01/01/2012 - "Despite the problem widely discussed in literature about remifentanil-induced hyperalgesia, no cases of analgesic overconsumption were registered in our study." 01/01/2012 - "Recent studies suggest that remifentanil, similar to other μ-opioid agonists, may induce hyperalgesia. "
4.	Respiratory Insufficiency (Respiratory Failure) 06/01/2015 - "(2) Respiratory depression was achieved with intravenous remifentanil (0.08 to 0.5 μg kg(-1) min(-1)). " 01/01/2015 - "At a dose of 1 μg/kg, remifentanil prior to induction of general anaesthesia increases the risk of neonatal respiratory depression during first minutes after caesarean delivery but duration of clinical symptoms is short. " 06/01/2012 - "The onset of and recovery from ventilatory depression were faster with remifentanil." 01/01/2012 - "Repinotan prevented remifentanil-induced ventilatory depression in spontaneously breathing, anesthetized rats. " 01/01/2012 - "Selective 5-HT(1A)-R-agonist repinotan prevents remifentanil-induced ventilatory depression and prolongs antinociception."
5.	Cough 09/01/2014 - "We designed this study to investigate the incidence of remifentanil-induced cough (RIC) in children and to evaluate the effect of injection speed on RIC. " 07/01/2012 - "This study evaluates the effectiveness of the target-controlled infusion (TCI) of remifentanil through stepwise increases in the effect-site concentration (C(eff)) in preventing coughs. " 11/01/2010 - "The effect of remifentanil on cough suppression after endoscopic sinus surgery: a randomized study." 12/01/2008 - "However, no study has assessed the occurrence of cough induced by remifentanil. " 06/01/2015 - "At a Ce of 2.0 ng/ml,remifentanil has better cough-preventing effect and more stable hemodynamic status in females than in males."

Related Drugs and Biologics

1.	Propofol (Diprivan)
2.	sevoflurane (Ultane)
3.	Fentanyl (Sublimaze)
4.	Lidocaine (Xylocaine)
5.	Ketamine
6.	Sufentanil (Sufenta)
7.	Morphine (MS Contin)
8.	Dexmedetomidine
9.	Alfentanil (Alfenta)
10.	rocuronium (rocuronium bromide)

Related Therapies and Procedures

1.	Analgesia
2.	Anesthesia
3.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)
4.	Epidural Analgesia
5.	General Anesthesia