cinalukast

structure given in first source; orally active LTD4 antagonist; an anti-asthmatic agent

Also Known As:

4-(3-(2-(4-cyclobutyl-2-thiazolyl)ethenyl)phenylamino)-2,2-diethyl-4-oxobutanoic acid; Ro 24-5913; Ro-24-5913

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

1.	Pneumonia (Pneumonitis) 11/15/1994 - "Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation."
2.	Bronchial Spasm 11/01/1991 - "Ro 24-5913 also blocks allergic bronchospasm mediated by endogenously generated leukotrienes in guinea pigs; the potency and duration of action is nearly equivalent to that seen as an antagonist of bronchoconstrictions produced by exogenous LTD4. "
3.	Hyperthermia 06/01/2010 - "The effect of hyperthermia on annexin V-binding was significantly blunted by the leukotriene receptor CysLT1 antagonist cinalukast (1 microM). "

1.	Ro 24-4736
2.	Leukotriene Receptors (Leukotriene Receptor)
3.	Leukotriene D4
4.	Annexin A5
5.	Leukotrienes