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2-nitro-3-methylimidazo(4,5-f)quinoline

structure given in first source

Also Known As:

IQ(NO2); nitro-IQ

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - 2-nitro-3-methylimidazo(4,5-f)quinoline: 3

Related Diseases

1.	Chromosome Aberrations (Chromosome Abnormalities) 02/01/1994 - "Multiple treatment with IQ or nitro-IQ induced significant chromosome aberrations time- and dose-dependently, the maximum frequency of chromosome aberrations in metaphase cells being 39 and 33% respectively, while that in controls was 1.1%. " 02/01/1994 - "Cumulative effects of chromosome aberrations and sister chromatid exchanges (SCEs) were studied in hepatocytes of F344 rats exposed in vivo to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) at doses of 12.5, 25 or 50 mg/kg body wt/day or 2-nitro-3-methylimidazo[4,5-f]quinoline (nitro-IQ) at doses of 12.5, 25 or 50 mg/kg body wt/day. " 11/01/1991 - "Intraperitoneal injections of Trp-P-1, Glu-P-1, MeIQx, IQ and nitro-IQ resulted in chromosome aberrations in up to 16% of the metaphase cells and SCEs at up to 0.9 per chromosome, while injections of Trp-P-2 and Glu-P-2 produced SCEs at up to 0.7 and 1.1 per chromosome, respectively. "
2.	Carcinogenesis 06/15/1999 - "We conclude that nonenzymatic reduction of nitro-IQ and resulting in oxidative DNA damage can play a role in carcinogenesis of IQ."

Related Drugs and Biologics

1.	quinoline
2.	Glu-P-2
3.	2- amino- 6- methyldipyrido(1,2- a- 3',2'- d)imidazole
4.	3-amino-1-methyl-5H-pyrido(4,3-b)indole
5.	3- amino- 1,4- dimethyl- 5H- pyrido(4,3- b)indole

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Injections