aureobasidin A

inositol phosphorylceramide synthase inhibitor; structure given in first source; isolated from the culture medium of Aureobasidium pullulans R 106

Also Known As:

cyclo-(D-Hmp(1)-L-MeVal(2)-L-Phe(3)-L-MePhe(4)-L-Pro(5)-L-aIle+ ++(6)-L-MeVal(7)-L-Leu(8)-L-betaHOMeVal(9))

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - aureobasidin A: 7
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - aureobasidin A: 7

Experts

1.	Berman, Judith: 1 article (10/2021)
2.	Fang, Ting: 1 article (10/2021)
3.	Jiang, Yuan-Ying: 1 article (10/2021)
4.	Lu, Hui: 1 article (10/2021)
5.	Wu, Hao: 1 article (10/2021)
6.	Yang, Feng: 1 article (10/2021)
7.	Del Poeta, Maurizio: 1 article (11/2020)
8.	Mota Fernandes, Caroline: 1 article (11/2020)
9.	Didier, A: 1 article (06/2000)
10.	Kurome, T: 1 article (06/2000)

Related Diseases

1.	Infections 11/17/2023 - "In the present study, aureobasidin A did not display antibiofilm activity nor synergism with amphotericin B, but its combination with fluconazole was effective against Candida biofilms and protected the host in an in vivo infection model. "
2.	Trisomy (Trisomies) 01/01/2023 - "Chromosome 1 trisomy confers resistance to aureobasidin A in Candida albicans." 01/01/2023 - "Importantly, chromosome 1 trisomy simultaneously regulated genes which were associated with aureobasidin A resistance that are on this aneuploid chromosome as well as on other chromosomes. " 10/31/2021 - "Interestingly, a specific aneuploidy including trisomy of chromosome 6 (Chr6x3) also enabled cross-tolerance to aureobasidin A (AbA), a sphingolipid biosynthesis inhibitor. "
3.	Neoplasms (Cancer) 03/01/1998 - "Cyclic depsipeptide antibiotic aureobasidin A (AbA) and its analogs were tested for the inhibitory activity of P-glycoprotein in multidrug resistant cancer cells as well as for the antifungal activity. " 06/29/2000 - "Cyclic depsipeptide cyclo-[D-Hmp(1)-L-MeVal(2)-L-Phe(3)-L-MePhe(4)-L-Pro(5)-L-aIle+ ++(6)-L-MeVal(7)-L-Leu(8)-L-betaHOMeVal(9)], the antifungal antibiotic aureobasidin A (AbA), was reported to interfere with ATP-binding cassette (ABC) transporters in yeast and mammalian cells, particularly the MDR1 P-glycoprotein (Pgp), a transmembrane phospholipid flippase or "hydrophobic vacuum cleaner" that mediates multidrug resistance (MDR) of cancer cells. "
4.	Aneuploidy (Aneuploid) 01/01/2023 - "Resistance to aureobasidin A was unstable because of the inherent instability of aneuploids. " 01/01/2023 - "Importantly, chromosome 1 trisomy simultaneously regulated genes which were associated with aureobasidin A resistance that are on this aneuploid chromosome as well as on other chromosomes. " 01/01/2023 - "Furthermore, the pleiotropic effect of aneuploidy caused altered resistance not only to aureobasidin A but also to other antifungal drugs including caspofungin and 5-flucytosine. " 10/31/2021 - "Interestingly, a specific aneuploidy including trisomy of chromosome 6 (Chr6x3) also enabled cross-tolerance to aureobasidin A (AbA), a sphingolipid biosynthesis inhibitor. "
5.	Mycoses (Diseases, Fungus) 04/11/1997 - "Now that IPC synthase has been shown to be the target for aureobasidin A, it should be possible to develop high throughput screens to identify new inhibitors of IPC synthase to combat fungal diseases."

Related Drugs and Biologics

1.	Fluconazole (Zonal)
2.	Amphotericin B (Amphotericin)
3.	Depsipeptides
4.	Member 1 Subfamily B ATP Binding Cassette Transporter
5.	Anti-Bacterial Agents (Antibiotics)
6.	aureobasidin A
7.	ATP-Binding Cassette Transporters (ABC Transporters)
8.	Sphingolipids
9.	Phospholipids (Phosphatides)
10.	Adenosine Triphosphate (ATP)