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dibenzo(a,l)pyrene 11,12-dihydrodiol
structure given in first source
Also Known As:
DB(a,l)P 11,12-dihydrodiol
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Pyrenes: 10
Benzopyrenes: 67
Dihydroxydihydrobenzopyrenes
dibenzo(a,l)pyrene 11,12-dihydrodiol: 1
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Pyrenes: 10
Benzopyrenes: 67
Dihydroxydihydrobenzopyrenes
dibenzo(a,l)pyrene 11,12-dihydrodiol: 1
Related Diseases
1.
Neoplasms (Cancer)
10/01/1991 - "
This experiment showed that in the mouse skin, DB[a,l]P and DB[a,l]P 11,12-dihydrodiol displayed similar tumor-initiating activity with a response inversely proportional to the dose, presumably due to the toxicity of the compounds.
"
10/01/1991 - "
Subsequently, the tumor-initiating activity of DB[a,l]P was compared in the skin of female SENCAR mice to that of DMBA, B[a]P, DB[a,l]P 8,9-dihydrodiol and DB[a,l]P 11,12-dihydrodiol at doses of 100, 20 and 4 nmol.
"
10/01/1991 - "
Comparative studies were conducted of the tumor-initiating activity in mouse skin and carcinogenicity in rat mammary gland of dibenzo[a,l]pyrene (DB[a,l]P) versus 7,12-dimethyl-benz[a]anthracene (DMBA), the most potent recognized carcinogenic polycyclic aromatic hydrocarbon (PAH); benzo[a]pyrene (B[a]P), the most potent recognized carcinogenic environmental PAH; DB[a,l]P 8,9-dihydrodiol, the K-region dihydrodiol; and DB[a,l]P 11,12-dihydrodiol, precursor to the bay-region diolepoxide.
"
Related Drugs and Biologics
1.
Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)
2.
Benzo(a)pyrene
3.
trans-1,2-dihydro-1,2-naphthalenediol
4.
dibenzo(a,l)pyrene 8,9-dihydrodiol
5.
dibenzo(a,l)pyrene
6.
benz(a)anthracene (benzanthracene)