astacin

a zinc-endopeptidase from the crayfish Astacus astacus & Hydra vulgaris; releases nitroaniline from succinyl-alanyl-alanyl-alanyl-4-nitroanilide (Suc-Ala-Ala-Ala-pNA); acts on peptides containing 5 or more amino acids, preferably with ALA in P1' and Pro in P2'

Also Known As:

Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sterchi, Erwin E: 5 articles (10/2012 - 10/2003)
2.	Stöcker, Walter: 4 articles (01/2020 - 03/2004)
3.	Ramsbeck, Daniel: 3 articles (05/2021 - 01/2017)
4.	Becker-Pauly, Christoph: 3 articles (12/2012 - 05/2007)
5.	Lottaz, Daniel: 3 articles (05/2008 - 03/2004)
6.	Jäger, Christian: 2 articles (05/2021 - 01/2020)
7.	Schilling, Stephan: 2 articles (05/2021 - 01/2017)
8.	Schlenzig, Dagmar: 2 articles (05/2021 - 01/2017)
9.	Chaudhuri, Ankur: 2 articles (04/2020 - 06/2019)
10.	Buchholz, Mirko: 2 articles (01/2020 - 01/2017)

Related Diseases

1.	Female Infertility 01/01/2020 - "A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment." 12/15/2023 - "In a recent study, a homozygous variant in astacin-like metalloendopeptidase (ASTL), which encodes the ovastacin enzyme that cleaves ZP2 to prevent polyspermy, was found to be associated with female infertility characterized by polyspermy in vitro. "
2.	Spider Bites (Spider Bite) 12/15/2013 - "Furthermore, our investigation implicates the brown spider venom as a source of Astacin-like proteases for use in loxoscelism studies, cell biology research and biotechnological applications. "
3.	Neoplasms (Cancer) 05/01/2007 - "Meprins are members of the astacin family of metalloproteases expressed in epithelial tissues, intestinal leukocytes and certain cancer cells. " 10/12/2012 - "Meprinα, an astacin-type metalloprotease is overexpressed in colorectal cancer cells and is secreted in a non-polarized fashion, leading to the accumulation of meprinα in the tumor stroma. " 05/14/2008 - "Meprin (EC 3.4.24.18), an astacin-like metalloprotease, is expressed in the epithelium of the intestine and kidney tubules and has been related to cancer, but the mechanistic links are unknown. " 02/06/2018 - "Here we characterize SAS1B (ovastacin, ASTL, astacin-like), a cancer-oocyte antigen, as an attractive immunotoxin target expressed at the surface of human pancreatic cancer cells, with limited expression among normal tissues. " 03/01/2004 - "Meprin is a zinc endopeptidase of the astacin family, which is expressed as a membrane-bound or secreted protein in mammalian epithelial cells, in intestinal leucocytes and in certain cancer cells. "
4.	Fibrosis (Cirrhosis) 05/26/2021 - "The astacin protease Meprin β represents an emerging target for drug development due to its potential involvement in disorders such as acute and chronic kidney injury and fibrosis. " 12/01/2015 - "Human meprin β (h-meprin β), a single-zinc metalloendoprotease of the astacin family, is potentially involved in disorders such as fibrosis and Alzheimer's disease. " 06/01/2019 - "Human meprin beta metalloprotease, a small subgroup of the astacin family, is a potent drug target for the treatment of several disorders such as fibrosis, neurodegenerative disease in particular Alzheimer and inflammatory bowel diseases. " 01/01/2017 - "The astacin proteases meprin α and β are emerging drug targets for treatment of disorders such as kidney failure, fibrosis or inflammatory bowel disease. " 04/01/2020 - "Human meprin-β, a zinc metalloprotease belonging to the astacin family, have been found to be associated with many pathological conditions like inflammatory bowel disease, fibrosis and neurodegenerative disease. "
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 06/01/2019 - "Human meprin beta metalloprotease, a small subgroup of the astacin family, is a potent drug target for the treatment of several disorders such as fibrosis, neurodegenerative disease in particular Alzheimer and inflammatory bowel diseases. " 01/01/2017 - "The astacin proteases meprin α and β are emerging drug targets for treatment of disorders such as kidney failure, fibrosis or inflammatory bowel disease. " 04/01/2020 - "Human meprin-β, a zinc metalloprotease belonging to the astacin family, have been found to be associated with many pathological conditions like inflammatory bowel disease, fibrosis and neurodegenerative disease. "

Related Drugs and Biologics

1.	Peptide Hydrolases (Proteases)
2.	Metalloendopeptidases (Metalloendopeptidase)
3.	Enzymes
4.	loxosceles venom
5.	Tiopronin (Thiola)
6.	Metalloproteases (Metalloproteinases)
7.	Zinc
8.	Proteins (Proteins, Gene)
9.	Neprilysin (Neutral Endopeptidase)
10.	Endopeptidases