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placenta growth factor

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amino acid sequence given in first source; related to the vascular permeability factor; do not confuse with PIGF protein involved in transfer of ethanolamine phosphate; RefSeq NM_002632 (human), NM_008827 (mouse), NM_053595 (rat)

Also Known As:

PGF protein, human; PIGF-1 protein, mouse; PLGF protein, human; Pgf protein, mouse; Pgf protein, rat; Plgf protein, mouse; Plgf protein, rat; placenta growth factor, PlGF-1 isoform; placenta growth factor, PlGF-2 isoform; placenta growth factor, PlGF-3 isoform; placental growth factor protein, mouse; placental growth factor protein, rat; placental growth factor-1, mouse

Networked: 169 relevant articles (1 outcomes, 24 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Pregnancy Proteins: 71
    - placenta growth factor: 169

Experts

1.	Kalra, Vijay K: 8 articles (06/2015 - 08/2003)
2.	Malik, Punam: 7 articles (06/2015 - 08/2003)
3.	Hsieh, Fon-Jou: 6 articles (09/2009 - 02/2004)
4.	Gonsalves, Caryn S: 4 articles (06/2015 - 08/2008)
5.	Ahmed, Asif: 4 articles (03/2015 - 12/2003)
6.	Cheng, Shih-Lung: 4 articles (01/2014 - 01/2011)
7.	Wei, Shu-Chen: 4 articles (01/2014 - 02/2004)
8.	Tsao, Po-Nien: 4 articles (01/2014 - 02/2004)
9.	Jain, Rakesh K: 4 articles (11/2013 - 04/2006)
10.	Cheng, Shih-Jung: 4 articles (05/2013 - 10/2010)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "Prognostic significance of placenta growth factor expression in patients with multiple cancers: a meta-analysis." 01/01/2015 - "Placenta growth factor is upregulated in many neoplastic diseases and serum levels of PlGF are increased in cancer patients following anti-angiogenic therapy. " 01/01/2014 - "Placenta growth factor promotes migration through regulating epithelial-mesenchymal transition-related protein expression in cervical cancer." 06/01/2012 - "Inhibition of placenta growth factor with TB-403: a novel antiangiogenic cancer therapy." 10/01/2010 - "Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers. "
2.	Pre-Eclampsia (Preeclampsia) 10/01/2001 - "The aim of this study was to investigate whether levels of placenta growth factor are decreased before the clinical onset of preeclampsia, and whether placenta growth factor levels are decreased in pregnancies complicated by intrauterine growth restriction. " 10/01/2001 - "Previous studies have shown decreased levels of placenta growth factor in serum of pregnant women with preeclampsia. " 08/01/2012 - "Decreased levels of serum placenta growth factor (PlGF) are associated with preeclampsia. " 08/01/2012 - "Examining the correlation between placental and serum placenta growth factor in preeclampsia." 08/01/2007 - "Second-trimester placenta growth factor levels are altered in patients who had severe preeclampsia develop."
3.	Colorectal Neoplasms (Colorectal Cancer) 12/01/2012 - "Expression of placenta growth factor in colorectal carcinomas." 04/01/2012 - "Elevated serum placenta growth factor levels are significantly associated with colorectal cancer development, lymph or distant invasive phenotypes and survival, especially in stage II or III patients." 04/01/2012 - "The serum placenta growth factor levels in colorectal cancer patients were compared with those in healthy controls, and we retrospectively assessed the association between serum placenta growth factor levels and clinicopathological findings and survival. " 04/01/2012 - "Preoperative serum placenta growth factor level as a new marker for stage II or III colorectal cancer patients." 09/01/2009 - "Preoperative serum placenta growth factor levels were higher in patients with colorectal cancer, were negatively correlated with the serum sFlt-1, and could be used as a prognostic indicator for recurrence and survival for colorectal cancer."
4.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2013 - "In our previous studies, COPD patients were noted to have higher levels of placenta growth factor (PlGF) in serum and bronchoalveolar lavage fluid than controls. " 06/01/2008 - "Increased expression of placenta growth factor in COPD." 01/01/2009 - "Although both animal and human studies suggested the association between placenta growth factor (PlGF) and chronic obstructive pulmonary disease (COPD), especially lung emphysema, the role of PlGF in the pathogenesis of emphysema remains to be clarified. " 06/01/2008 - "The effect of another angiogenic factor, placenta growth factor (PlGF), in chronic obstructive pulmonary disease (COPD) is unknown. " 01/01/2011 - "Elevated placenta growth factor predicts pneumonia in patients with chronic obstructive pulmonary disease under inhaled corticosteroids therapy."
5.	Anoxia (Hypoxia) 07/02/2010 - "Placenta growth factor-induced early growth response 1 (Egr-1) regulates hypoxia-inducible factor-1alpha (HIF-1alpha) in endothelial cells." 04/01/2009 - "Metal transcription factor-1 is involved in hypoxia-dependent regulation of placenta growth factor in trophoblast-derived cells." 02/01/2009 - "Hypoxia increases placenta growth factor expression in human myocardium and cultured neonatal rat cardiomyocytes." 03/15/2001 - "Placenta growth factor gene expression is induced by hypoxia in fibroblasts: a central role for metal transcription factor-1." 09/01/2013 - "As placenta growth factor (PlGF) promotes pathological angiogenesis by acting on the growth, migration and survival of endothelial cells, there may be some connections between PlGF and 15-LO in hypoxia induced endothelial cells proliferation. "

Related Drugs and Biologics

1.	Biological Markers (Surrogate Marker)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Tyrosine (L-Tyrosine)
4.	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)
5.	Carcinoembryonic Antigen
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)
7.	Angiogenesis Inducing Agents (Angiogenesis Factor)
8.	Messenger RNA (mRNA)
9.	Vascular Endothelial Growth Factor B
10.	Thymidine Phosphorylase

Related Therapies and Procedures

1.	Radioimmunotherapy
2.	Heterologous Transplantation (Xenotransplantation)