discodermolide

a lactone-bearing polyhydroxylated alkatetraene from the marine sponge Discodermia dissoluta; microtubule-stabilizing agent like taxol

Also Known As:

2H-Pyran-2-one, 6-(14-((aminocarbonyl)oxy)-2,6,12-trihydroxy-5,7,9,11,13,15-hexamethyl-3,8,16,18-nonadecatetraenyl)tetrahydro-4-hydroxy-3,5-dimethyl-, (3S-(3alpha,4beta,5beta,6alpha(2R*,3Z,5R*,6R*,7S*,8Z,11R*,12S*,13S*,14S*,15R*,16E)))-

Networked: 31 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Horwitz, Susan Band: 6 articles (01/2018 - 04/2002)
2.	Smith, Amos B: 6 articles (01/2018 - 03/2005)
3.	Paterson, Ian: 6 articles (12/2017 - 12/2005)
4.	McDaid, Hayley M: 3 articles (01/2018 - 01/2006)
5.	Wright, Amy E: 3 articles (01/2010 - 05/2007)
6.	Freeze, B Scott: 3 articles (01/2006 - 03/2005)
7.	Yang, Chia-Ping Huang: 2 articles (01/2018 - 04/2013)
8.	Goldberg, Gary L: 2 articles (04/2013 - 01/2006)
9.	Naylor, Guy J: 2 articles (01/2010 - 10/2008)
10.	Gardner, Nicola M: 2 articles (05/2007 - 01/2007)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2001 - "The study reported here is the first to provide information on the structure-activity relationships of discodermolide using human tumor cells and analogs produced by semisynthetic modification of natural discodermolide." 01/04/2011 - "Consistent with this, cell growth and response to discodermolide was confirmed in vivo using tumor xenograft models. " 06/11/2004 - "(+)-discodermolide: a marine natural product against cancer." 12/01/2003 - "Discodermolide is a new microtubule-targeted drug in Phase I clinical trials that inhibits tumor growth and induces G(2)-M cell cycle arrest. " 12/01/2003 - "Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation."
2.	Breast Neoplasms (Breast Cancer) 01/09/1996 - "Discodermolide-treated breast carcinoma cells displayed spectacular rearrangement of the microtubule cytoskeleton, including extensive microtubule bundling. " 01/01/1998 - "Because paclitaxel shows clinical promise for breast cancer treatment, its effects in a series of human breast cancer cells were compared to those of (+)-discodermolide. " 01/01/1998 - "The potent microtubule-stabilizing agent (+)-discodermolide induces apoptosis in human breast carcinoma cells--preliminary comparisons to paclitaxel."
3.	Splenomegaly 10/01/1991 - "Discodermolide was effective in suppressing the graft-versus-host splenomegaly response of BALB/c----CB6F1 (BALB/c X C57BL/6J)F1 grafted mice at 5.0, 2.5, and 1.25 mg/kg, when administered as daily, i.p. "
4.	Hepatocellular Carcinoma (Hepatoma) 09/01/2005 - "The current study showed that paclitaxel, discodermolide, and an analogue of epothilone B, BMS-247550, induced CYP3A4 protein expression in HepG2 hepatoma cells. "
5.	Carcinoma (Carcinomatosis) 03/01/2005 - "Selection of A549 nonsmall cell lung carcinoma cells with increasing concentrations of discodermolide yielded a clone that proliferated in 8 nM. When these cells were exposed to any concentration greater than 8 nM, replication ceased and the cells developed a flattened, enlarged, granular morphology. " 01/01/2006 - "The combination index method was used to evaluate the interaction of Taxol and discodermolide in human ovarian SKOV-3 carcinoma cells. " 01/01/2006 - "Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice." 01/01/2006 - "Taxol and discodermolide interact synergistically over a range of concentrations and molar ratios that cause drug-induced aneuploidy in ovarian carcinoma cells. " 05/01/2000 - "Median effect analysis using the combination index method revealed a schedule-independent synergistic interaction between Taxol and discodermolide in four human carcinoma cell lines, an effect that was not observed between Taxol and epothilone B. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	epothilone B (EPO906)
3.	Peptides (Polypeptides)
4.	eleutherobin
5.	bryostatin 1
6.	Cytochrome P-450 CYP3A
7.	Depsipeptides
8.	Proteins (Proteins, Gene)
9.	Trabectedin
10.	girolline

Related Therapies and Procedures

1.	Therapeutics

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