BDF 9148

sodium channel activator; structure given in first source; BDF 9196 - S enantiomer; LY-341311 is the (S)-isomer and monohydrate

Also Known As:

4-(3-((1-(diphenylmethyl)-3-azetidinyl)oxy)-2-hydroxypropoxy)-1H-indole-2-carbonitrile monohydrate; 4-(3-(1-diphenylmethylazetidine-3-oxy)-2-hydroxypropoxy)-1H-indole-2-carbonitrile; BDF 9196; BDF-9148; BDF-9196; BDF9196; LY 341311; LY 366634; LY-341311; LY341311; LY366634; 1H-Indole-2-carbonitrile, 4-(3-((1-(diphenylmethyl)-3-azetidinyl)oxy)-2-hydroxypropoxy)-

Networked: 14 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azetines
    - Azetidines: 6
      - BDF 9148: 14

Experts

1.	Gill, Robert M: 2 articles (11/2002 - 02/2002)
2.	Jones, Bonita D: 2 articles (11/2002 - 02/2002)
3.	Shen, Weiqun: 2 articles (11/2002 - 02/2002)
4.	Steinberg, Mitchell I: 2 articles (11/2002 - 02/2002)
5.	Hackmann, Frank: 1 article (12/2003)
6.	Hellige, Gerhard: 1 article (12/2003)
7.	Hoebel, Dyrken: 1 article (12/2003)
8.	Luers, Frank: 1 article (12/2003)
9.	Pfahlberg, Annette: 1 article (12/2003)
10.	Rizouli, Vicky: 1 article (12/2003)

Related Diseases

1.	Heart Failure 03/01/1999 - "Thus, BDF 9148 may have some potential for the treatment of heart failure." 04/01/1997 - "The enhanced sensitivity of the failing human myocardium towards Na(+)-channel modulation is not due to a direct or indirect interaction of (+/-)BDF 9148 with cardiac myofilaments but may be due to an altered Na(+)-homeostasis in human heart failure." 05/01/1995 - "BDF 9148 or similar drugs may have potential as positive inotropes in the treatment of heart failure." 08/01/1994 - "Our results indicate: (i) that BDF 9148 is as effective as DPI 201-106 in increasing force of contraction and prolonging action potential duration in human ventricular myocardium: (ii) that BDF 9148 is effective in enhancing force of contraction, in spite of heart failure; (iii) that the positive inotropic effect is related to an increased Na+ load; and (iv) due to action potential duration prolongation, changes in Q-T interval of the electrocardiogram could be possible during in vivo use of BDF 9148." 03/01/1999 - "2. We studied the effects of BDF 9148 on the action potentials and contractions of left ventricles from 5-week-old prehypertensive, 14-week-old hypertensive, 6- and 12-month-old hypertension-associated hypertrophy and 18-month-old hypertension-induced heart failure SHR and age-matched Wistar-Kyoto normotensive (WKY) rats. "
2.	Hypertension (High Blood Pressure) 03/01/1999 - "Similar effects were observed with BDF 9148 in the early stages of hypertension (14-week-old SHR). " 02/01/1998 - "The aims of our study were to determine the mechanism of action of BDF 9148, and to ascertain whether the relaxing effect of BDF 9148 was maintained in the presence of the hypertrophy associated with hypertension, by investigating the effects of BDF 9148 on the contractility and electrophysiology of aortae of Wistar Kyoto normo-tensive rats (WKY) and Spontaneously Hypertensive Rats (SHRs). " 03/01/1999 - "5. In the presence of persistent hypertension-associated hypertrophy of the SHR left ventricle at > or = 6 months, the effects of BDF 9148 on action potentials and contractions were significantly reduced to a small extent. " 03/01/1999 - "2. We studied the effects of BDF 9148 on the action potentials and contractions of left ventricles from 5-week-old prehypertensive, 14-week-old hypertensive, 6- and 12-month-old hypertension-associated hypertrophy and 18-month-old hypertension-induced heart failure SHR and age-matched Wistar-Kyoto normotensive (WKY) rats. " 06/01/1995 - "1. This study has defined the positive inotropic responses to the sodium channel modulator BDF 9148 in rats with hypertension, thyroid dysfunction, diabetes or dwarfism. "
3.	Hypertrophy 03/01/1999 - "6. In summary, most of the response of BDF 9148 is maintained in the presence of hypertrophy and failure. " 02/01/1998 - "The aims of our study were to determine the mechanism of action of BDF 9148, and to ascertain whether the relaxing effect of BDF 9148 was maintained in the presence of the hypertrophy associated with hypertension, by investigating the effects of BDF 9148 on the contractility and electrophysiology of aortae of Wistar Kyoto normo-tensive rats (WKY) and Spontaneously Hypertensive Rats (SHRs). " 03/01/1999 - "5. In the presence of persistent hypertension-associated hypertrophy of the SHR left ventricle at > or = 6 months, the effects of BDF 9148 on action potentials and contractions were significantly reduced to a small extent. " 03/01/1999 - "1. The aim of the present study was to test the hypothesis that responses to BDF 9148, which prolongs the opening of sodium channels, are reduced in the spontaneously hypertensive rat (SHR) left ventricle in the presence of hypertrophy and failure. " 02/01/1998 - "BDF 9148 had no effect on the quiescent, but relaxed the KCl-contracted WKY and SHR aorta by a tetrodotoxin insensitive mechanism, and these relaxations decreased with age but were not greatly altered by hypertrophy. "
4.	Cardiac Arrhythmias (Arrythmia) 12/01/2003 - "Further studies are necessary to clarify the risk of arrhythmia during application of Na+-channel modulators such as BDF 9148." 06/01/2000 - "Incidences of new arrhythmia were comparable in the lower dose regimens, ranging from 16.7% (3/18 animals with BDF 9148) to 31.6% (6/19 animals with DPI 201-106), and in the higher dose regimens, ranging from 10.0% (1/10 animals with milrinone) to 27.7% (5/18 animals with DPI 201-106). "
5.	Dwarfism 06/01/1995 - "1. This study has defined the positive inotropic responses to the sodium channel modulator BDF 9148 in rats with hypertension, thyroid dysfunction, diabetes or dwarfism. "

Related Drugs and Biologics

1.	Sodium Channels (Sodium Channel)
2.	DPI 201-106
3.	Sodium Channel Agonists
4.	Ouabain (G Strophanthin)
5.	Isoproterenol (Isoprenaline)
6.	Dobutamine
7.	Milrinone (Primacor)
8.	Tetrodotoxin (Tetradotoxin)
9.	Sodium
10.	Adrenergic Receptors (Adrenergic Receptor)

Related Therapies and Procedures

1.	Heart Transplantation (Grafting, Heart)