To autoantigen

reognized by sera from some patients with autoimmune disease; an integral component of both human RNase P & mitochondrial RNA processing (MRP) RNase; amino acid sequence has been determined

Networked: 34 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Alaverdian, Diana: 1 article (01/2022)
2.	Amoroso, Antonio: 1 article (01/2022)
3.	Aslaksen, Sigrid: 1 article (01/2022)
4.	Baldassarri, Margherita: 1 article (01/2022)
5.	Beligni, Giada: 1 article (01/2022)
6.	Benetti, Elisa: 1 article (01/2022)
7.	Boitard, Christian: 1 article (01/2022)
8.	Campolo, Federica: 1 article (01/2022)
9.	Carriero, Miriam Lucia: 1 article (01/2022)
10.	Chiariello, Mario: 1 article (01/2022)

Related Diseases

1.	Prostatitis 07/01/1994 - "The result that even CD4+ cells from Orx-0 mice that were thymectomized as adults and treated thereafter with DHT were effective for prevention of prostatitis suggests that activation of this Ts population takes place in the peripheral lymphoid organs, and that it maintains peripheral tolerance to autoantigen in the prostate of these mice and probably also in normal mice."
2.	Autoimmune Diseases (Autoimmune Disease) 07/01/2006 - "Strategies to cure autoimmune disease must not only establish immunological tolerance to autoantigen, but also rid the organ of pathogenic autoreactive cells. " 12/01/2002 - "Thus, autoimmune diseases result from epigenetic changes that lead to autoantigen generation." 06/01/2000 - "Both active and passive tolerance mechanisms, therefore, contribute to autoantigen:IFA-induced protection from autoimmune disease." 04/01/1992 - "Immunointervention in autoimmune diseases from cellular selectivity to autoantigen specificity." 01/01/2019 - "Hashimoto thyroiditis (HT) is an autoimmune disease that presumably arises consequent to loss of immune tolerance to autoantigen in thyroid. "
3.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 08/01/2004 - "Presence of these high-avidity TcRs indicates a failure to delete autoreactive T-cells that likely arise from oligoclonal expansion in response to autoantigen exposure during the progression of type 1 diabetes." 11/01/2001 - "Islet allotransplantation into patients with autoimmune type 1 diabetes represents a reexposure to autoantigen. " 01/01/2022 - "Preclinical Models to Evaluate the Human Response to Autoantigen and Antigen-Specific Immunotherapy in Human Type 1 Diabetes." 01/01/2016 - "Administration with SGAD65190-315 /IL-10 blocked the onset of autoimmune diabetes in NOD mice, significantly suppressed islet inflammation, inhibited the apoptosis of islet β cells, induced immune tolerance to autoantigen GAD65 and proinsulin and shifted the Th1/Th2 balance towards Th2. "
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/01/1979 - "Altered function of suppressor T lymphocytes in patients with active systemic lupus erythematosus--in vitro immune response to autoantigen." 12/01/2015 - "An imbalance between neutrophil extracellular trap (NET) formation and degradation has been described in systemic lupus erythematosus (SLE), potentially contributing to autoantigen externalisation, type I interferon synthesis and endothelial damage. "
5.	Inflammation (Inflammations) 01/01/2016 - "Administration with SGAD65190-315 /IL-10 blocked the onset of autoimmune diabetes in NOD mice, significantly suppressed islet inflammation, inhibited the apoptosis of islet β cells, induced immune tolerance to autoantigen GAD65 and proinsulin and shifted the Th1/Th2 balance towards Th2. " 03/01/2009 - "This indicates that molecular mimicry between CMV peptide and tyrosinase plays an important role in the immunopathogenic mechanisms by which CD4+ T lymphocytes are sensitized to autoantigen of tyrosinase and cause inflammation in VKH disease. "

Related Drugs and Biologics

1.	Autoantibodies
2.	Antigens
3.	Autoantigens
4.	Peptides (Polypeptides)
5.	Antibodies
6.	Sialic Acid Binding Ig-like Lectin 1
7.	Toll-Like Receptors (Toll-Like Receptor)
8.	Monophenol Monooxygenase (Tyrosinase)
9.	Proinsulin
10.	Interferon Type I

Related Therapies and Procedures

1.	Transplantation
2.	Immunotherapy