O-sialoglycoprotein endopeptidase

specific for O-sialoglycoproteins such as glycophorin A

Also Known As:

GCPL1 protein, human; O-glycosylated glycoprotein protease; O-sialoglycoprotein endopeptidase protein, human; O-sialoglycoprotein endopeptidase, mouse; O-sialoglycoprotein endopeptidase, rat; OSGEP protein, human; OSGEP1 protein, human; Osgep protein, mouse; Osgep protein, rat; PRSMG1 protein, human; glycophorin A protease; hSMG-1 protein, human; sialoglycoprotease

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        O-sialoglycoprotein endopeptidase: 6
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        O-sialoglycoprotein endopeptidase: 6

Experts

1.	Alfadda, Assim A: 1 article (01/2022)
2.	Alhasan, Khalid: 1 article (01/2022)
3.	Ali Alghamdi, Malak: 1 article (01/2022)
4.	Alkhalidi, Hisham: 1 article (01/2022)
5.	Alorainy, Ibrahim A: 1 article (01/2022)
6.	Alsheikh, Hamad: 1 article (01/2022)
7.	Bashiri, Fahad A: 1 article (01/2022)
8.	Benabdelkamel, Hicham: 1 article (01/2022)
9.	Bertoli-Avella, Aida M: 1 article (01/2022)
10.	Guatibonza Moreno, Pilar: 1 article (01/2022)

Related Diseases

1.	Carcinoma (Carcinomatosis) 10/01/2000 - "O-Sialoglycoprotein endopeptidase treatment revealed that on carcinomas and cell lines, the epitope was present on O-glycans. " 06/01/2001 - "The initial organ colonization of intravenously injected carcinoma cells is attenuated in P-selectin-deficient mice, in mice receiving tumor cells pretreated with O-sialoglycoprotease (to selectively remove mucins from cell surfaces), or in mice receiving a single dose of heparin prior to tumor cell injection. " 05/01/1997 - "Latex beads coated with purified CD24 from the two carcinoma cell lines but also neutrophils could bind specifically to P-selectin-IgG. The binding was dependent on divalent cations and was abolished by treatment with O-sialoglycoprotein endopeptidase but not endoglycosidase F or sialidase. "
2.	Neoplasms (Cancer) 12/01/2001 - "Treatment of cancer cells with O-sialoglycoprotease did not decrease either the binding of anti-sialosyl Le(a) antibodies or binding to E-selectin-expressing CHO cells. " 06/01/2001 - "The initial organ colonization of intravenously injected carcinoma cells is attenuated in P-selectin-deficient mice, in mice receiving tumor cells pretreated with O-sialoglycoprotease (to selectively remove mucins from cell surfaces), or in mice receiving a single dose of heparin prior to tumor cell injection. "
3.	Pneumonic Pasteurellosis (Shipping Fever) 02/01/1997 - "The O-sialoglycoprotein endopeptidase (glycoprotease, Gcp) is secreted by Pasteurella haemolytica A1, a Gram-negative pathogen associated with bovine pneumonic pasteurellosis. "
4.	Galloway Mowat syndrome 01/01/2022 - "Genomic, Proteomic, and Phenotypic Spectrum of Novel O-Sialoglycoprotein Endopeptidase Variant in Four Affected Individuals With Galloway-Mowat Syndrome."

Related Drugs and Biologics

1.	P-Selectin
2.	E-Selectin
3.	Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
4.	Polysaccharides (Glycans)
5.	Neuraminidase (Sialidase)
6.	Mucins
7.	Immunoglobulin G (IgG)
8.	Heparin (Liquaemin)
9.	Divalent Cations
10.	Epitopes

Related Therapies and Procedures

1.	Microspheres (Microsphere)