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NIK 228

structure given in first source

Also Known As:

3-hydroxymethyl-2-methylimidazo(2,1-b)benzothiazole; NIK-228; Imidazo(2,1-b)benzothiazole-3-methanol, 2-methyl-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Benzothiazoles: 40
        NIK 228: 1
    - Imidazoles: 150
      - NIK 228: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiazoles: 40
      - NIK 228: 1

Related Diseases

1.	Ulcer 05/01/1991 - "Water-immersion stress-, indomethacin- or pylorus ligation (Shay)-induced gastric ulcers were dose-dependently inhibited by NIK-228 (10 to 100 mg/kg), but only water-immersion stress and indomethacin induced ulcers were dose-dependently inhibited by famotidine (0.03 to 3 mg/kg). "
2.	Stomach Ulcer (Gastric Ulcer) 05/01/1991 - "Water-immersion stress-, indomethacin- or pylorus ligation (Shay)-induced gastric ulcers were dose-dependently inhibited by NIK-228 (10 to 100 mg/kg), but only water-immersion stress and indomethacin induced ulcers were dose-dependently inhibited by famotidine (0.03 to 3 mg/kg). "
3.	Duodenal Ulcer (Curling's Ulcer) 05/01/1991 - "Cysteamine-induced duodenal ulcer was inhibited significantly by NIK-228 (30, 100 mg/kg) or famotidine (3 mg/kg). "

Related Drugs and Biologics

1.	Famotidine (Pepcid)
2.	Indomethacin (Indometacin)
3.	Cysteamine (Mercaptamine)

Related Therapies and Procedures

1.	Ligation