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NIK 228
structure given in first source
Also Known As:
3-hydroxymethyl-2-methylimidazo(2,1-b)benzothiazole; NIK-228; Imidazo(2,1-b)benzothiazole-3-methanol, 2-methyl-
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Thiazoles: 392
Benzothiazoles: 40
NIK 228: 1
Imidazoles: 150
NIK 228: 1
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzothiazoles: 40
NIK 228: 1
Related Diseases
1.
Ulcer
05/01/1991 - "
Water-immersion stress-, indomethacin- or pylorus ligation (Shay)-induced gastric ulcers were dose-dependently inhibited by NIK-228 (10 to 100 mg/kg), but only water-immersion stress and indomethacin induced ulcers were dose-dependently inhibited by famotidine (0.03 to 3 mg/kg).
"
2.
Stomach Ulcer (Gastric Ulcer)
05/01/1991 - "
Water-immersion stress-, indomethacin- or pylorus ligation (Shay)-induced gastric ulcers were dose-dependently inhibited by NIK-228 (10 to 100 mg/kg), but only water-immersion stress and indomethacin induced ulcers were dose-dependently inhibited by famotidine (0.03 to 3 mg/kg).
"
3.
Duodenal Ulcer (Curling's Ulcer)
05/01/1991 - "
Cysteamine-induced duodenal ulcer was inhibited significantly by NIK-228 (30, 100 mg/kg) or famotidine (3 mg/kg).
"
Related Drugs and Biologics
1.
Famotidine (Pepcid)
2.
Indomethacin (Indometacin)
3.
Cysteamine (Mercaptamine)
Related Therapies and Procedures
1.
Ligation