N- cyano- N'- (2- nitroxyethyl)- 3- pyridinecarboximidamide methanesulfonate

06/01/1993 - "These unique features of KRN2391 and nicorandil appear to be beneficial in ischaemic heart disease."
07/01/1993 - "Therefore,the protective effects of KRN2391, nicorandil and diltiazem on ET-l-induced heart disorders appear to be due to their direct actions on coronary vascular smooth muscle and the myocardium."

06/01/1997 - "The results of the present study show that KRN2391 is effective in reducing afterload during induced hypotension, and suggest that the hemodynamic profiles of KRN2391-induced hypotension are a hyperdynamic state as expressed by twofold increases in CI concomitant with the increase in right ventricular filling pressures. "
09/01/1997 - "While both drugs were equally able of inducing hypotension, our results show that the haemodynamic profile of KRN2391- and nicardipine-induced hypotension was a hyperdynamic state expressed by the marked increase in cardiac index with varying changes in right and left ventricular filling pressures, and suggest that KRN2391 may be a useful vasodilator for induced hypotension."

07/01/1994 - "7. The pharmacological properties of KRN2391 are thought to be beneficial for the treatment of patients with ischemic heart disease."
07/01/1992 - "Thus, KRN2391 may be useful to treat ischemic heart disease, because it increases the coronary blood flow and the oxygen supply to the heart, and decreases the afterload and the myocardial oxygen consumption."

02/16/1993 - "After 30 min of reperfusion, pretreatment with KRN2391 and cromakalim resulted in a significant improvement in cardiac function, ischemic contracture and biochemical parameters. "

02/16/1993 - "Thus, both KRN2391 and cromakalim have beneficial effects on biochemical parameters during ischemia and reperfusion, effects which may be related to cardiodepression during ischemia."
02/16/1993 - "The effects of two structurally different K+ channel openers, KRN2391 and cromakalim, on cardiac mechanisms during ischemia and reperfusion were studied in isolated perfused rat hearts. "
11/05/1991 - "Before ischemia, KRN2391 (1-10 microM) and nicorandil (10-1000 microM) increased coronary flow, but did not modify the cardiac mechanical function. "
01/01/1994 - "3. In two-stage coronary ligation-induced arrhythmia, KRN2391 inhibited arrhythmia at 48 hr. 4. These results suggest that KRN2391 may be effective on arrhythmia related to ischemia. "
02/16/1993 - "Isolated buffer-perfused rat hearts pretreated with KRN2391, cromakalim and vehicle were subjected to 25 min of ischemia followed by 30 min of reperfusion. "