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2'-deoxy-4'-thiocytidine

RN & structure given in first source

Also Known As:

2-DTCD; 4'-thio-2'-deoxycytidine

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hollingshead, Melinda: 2 articles (01/2021 - 08/2014)
2.	Haraguchi, Kazuhiro: 1 article (01/2022)
3.	Kumamoto, Hiroki: 1 article (01/2022)
4.	Tanaka, Hiromichi: 1 article (01/2022)
5.	Difilippantonio, Michael: 1 article (01/2021)
6.	Doroshow, James H: 1 article (01/2021)
7.	Kinders, Robert J: 1 article (01/2021)
8.	Larenjeira, Angelo B A: 1 article (01/2021)
9.	Nguyen, Dat: 1 article (01/2021)
10.	Rubinstein, Larry: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Seventeen cancer cell lines and multiple xenograft models bearing representative human solid tumors were subjected to 4'-thio-2'-deoxycytidine (T-dCyd) or control treatment. " 01/01/2021 - "TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models." 08/01/2014 - "Herein, we identified two novel 2'-deoxycytidine (dCyd) analogs, 4'-thio-2'-deoxycytidine (T-dCyd) and 5-aza-4'-thio-2'-deoxycytidine (aza-T-dCyd) that potently deplete DNMT1 in both in vitro and in vivo models of cancer and concomitantly inhibit tumor growth. "
2.	T-Cell Leukemia (Leukemia, T Cell) 01/01/2022 - "In terms of antineoplastic activity, 4'-azido- and 4'-C-fluoromethyl-2'-deoxy-4'-thiocytidine inhibited proliferation of human B-cell (CCRF-SB) and T-cell leukemia (Molt-4) cell lines, although the parent compound 2'-deoxy-4'-thiocytidine did not exhibit any cytotoxicity up to 100 μM. "

Related Drugs and Biologics

1.	Antineoplastic Agents (Antineoplastics)