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hemoglobin SAD

artificially engineered mutant hemoglobin combining the mutant features of Hb S Antilles and Hb D Punjab

Also Known As:

HB SAD

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        Sickle Hemoglobin: 1024
        hemoglobin SAD: 5
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        Sickle Hemoglobin: 1024
        hemoglobin SAD: 5

Experts

1.	Anderson, Kathleen P: 1 article (12/2007)
2.	Danton, Mary Jo: 1 article (12/2007)
3.	Daugherty, Cynthia: 1 article (12/2007)
4.	Degen, Jay L: 1 article (12/2007)
5.	Franco, Robert S: 1 article (12/2007)
6.	Girdler, Benjamin: 1 article (12/2007)
7.	Grimes, Timothy: 1 article (12/2007)
8.	Jiang, Maorong: 1 article (12/2007)
9.	Joiner, Clinton H: 1 article (12/2007)
10.	Roszell, Nancy J: 1 article (12/2007)

Related Diseases

1.	Afibrinogenemia (Fibrinogen Deficiency) 12/01/2007 - "The combination of Hb SAD and fibrinogen deficiency had a greater effect on mortality than that obtained by adding the mortality risks of each defect alone. " 12/01/2007 - "The deleterious effect of the combination of Hb SAD and fibrinogen deficiency on mortality was accelerated by hypoxia. " 12/01/2007 - "Fibrinogen deficiency dramatically reduced the survival of mice with Hb SAD to a much greater degree than mice with normal hemoglobin. "
2.	Hypoxia (Hypoxemia) 12/01/2007 - "The deleterious effect of the combination of Hb SAD and fibrinogen deficiency on mortality was accelerated by hypoxia. " 11/01/1991 - "Hemoglobin SAD was increased to 26% in beta-thal/SAD-1 mice which exhibited: (i) abnormal erythrocytes with regard to shape and density; (ii) an enlarged spleen and a high reticulocyte count indicating an increased erythropoiesis; (iii) mortality upon hypoxia; (iv) polymerization of hemolysate similar to that obtained in human homozygous sickle cell disease; and (v) anemia and mortality during development." 08/01/2007 - "The authors tested the hypothesis that the novel hemoglobin-based oxygen carrier, HRC 101, would improve survival during exposure to acute hypoxia in a murine model of sickle cell disease, the transgenic mouse expressing hemoglobin SAD (alpha2beta2). "
3.	Sickle Cell Anemia (Hemoglobin S Disease) 11/01/1991 - "Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD." 01/01/1990 - "Towards a mouse model for sickle cell disease: HB SAD." 11/01/1991 - "Hemoglobin SAD was increased to 26% in beta-thal/SAD-1 mice which exhibited: (i) abnormal erythrocytes with regard to shape and density; (ii) an enlarged spleen and a high reticulocyte count indicating an increased erythropoiesis; (iii) mortality upon hypoxia; (iv) polymerization of hemolysate similar to that obtained in human homozygous sickle cell disease; and (v) anemia and mortality during development." 08/01/2007 - "The authors tested the hypothesis that the novel hemoglobin-based oxygen carrier, HRC 101, would improve survival during exposure to acute hypoxia in a murine model of sickle cell disease, the transgenic mouse expressing hemoglobin SAD (alpha2beta2). "
4.	Splenomegaly 11/01/1991 - "Hemoglobin SAD was increased to 26% in beta-thal/SAD-1 mice which exhibited: (i) abnormal erythrocytes with regard to shape and density; (ii) an enlarged spleen and a high reticulocyte count indicating an increased erythropoiesis; (iii) mortality upon hypoxia; (iv) polymerization of hemolysate similar to that obtained in human homozygous sickle cell disease; and (v) anemia and mortality during development."
5.	Dehydration (Water Stress) 10/01/1995 - "Erythrocytes containing Hb SAD exhibited dehydration, increased maximal rate of Na(+)-K+ pump, unchanged Rb+ flux via the Gardos channel, and increased K(+)-Cl- cotransport. "

Related Drugs and Biologics

1.	Hemoglobins (Hemoglobin)
2.	Oxygen (Dioxygen)
3.	HRC 101