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CDC48 protein

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originally described as a precursor protein containing a biologically active peptide valosin

Also Known As:

CDC48 protein, S cerevisiae; CDC48 protein, mouse; IBMPFD protein, human; VCP protein, human; Vcp protein, mouse; Vcp protein, rat; YDL126C protein, S cerevisiae; cell cycle protein CDC48; cell cycle protein CDC48p; p97 valosin-containing protein; valosin containing protein, mouse; valosin-containing protein; valosin-containing protein, human; valosin-containing protein, rat; valosine-containing protein

Networked: 175 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kimonis, Virginia E: 22 articles (05/2015 - 04/2004)
2.	Nalbandian, Angèle: 14 articles (05/2015 - 01/2010)
3.	Tomita, Yasuhiko: 13 articles (07/2009 - 02/2003)
4.	Aozasa, Katsuyuki: 13 articles (07/2009 - 02/2003)
5.	Llewellyn, Katrina J: 9 articles (05/2015 - 01/2012)
6.	Weihl, Conrad C: 9 articles (04/2015 - 01/2006)
7.	Hoshida, Yoshihiko: 9 articles (11/2005 - 02/2003)
8.	Yamamoto, Shinji: 9 articles (11/2005 - 02/2003)
9.	Nguyen, Christopher: 8 articles (02/2015 - 11/2011)
10.	Vesa, Jouni: 7 articles (05/2015 - 11/2009)

Related Diseases

1.	Muscular Diseases (Myopathy) 03/15/2013 - "mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy." 11/01/2009 - "Valosin containing protein associated inclusion body myopathy: abnormal vacuolization, autophagy and cell fusion in myoblasts." 10/01/2008 - "One form of FTD-U, due to mutations in the valosin containing protein (VCP) gene, occurs with an inclusion body myopathy (IBMPFD). " 04/01/2015 - "Mutations of the valosin containing protein are instead responsible for hereditary inclusion-body myopathy with Paget's disease of the bone and frontotemporal dementia (IBMPFD), with these three phenotypic features having a variable penetrance. " 03/01/2015 - "Accumulating evidence has proven that mutations in the VCP gene encoding valosin-containing protein (VCP) cause inclusion body myopathy with Paget disease of the bone and frontotemporal dementia. "
2.	Frontotemporal Dementia 03/01/2005 - "Mutant valosin-containing protein causes a novel type of frontotemporal dementia." 04/01/2015 - "Mutations of the valosin containing protein are instead responsible for hereditary inclusion-body myopathy with Paget's disease of the bone and frontotemporal dementia (IBMPFD), with these three phenotypic features having a variable penetrance. " 03/01/2015 - "Accumulating evidence has proven that mutations in the VCP gene encoding valosin-containing protein (VCP) cause inclusion body myopathy with Paget disease of the bone and frontotemporal dementia. " 02/01/2015 - "Inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia is attributed to mutations in the valosin-containing protein (VCP) gene, mapped to chromosomal region 9p13.3-12. " 04/01/2014 - "Inclusion-body myopathy with Paget's disease of the bone and frontotemporal dementia (IBMPFD) is a rare, late-onset autosomal disorder arising from missense mutations in a gene coding for valosin-containing protein. "
3.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/23/2015 - "A patient with familial amyotrophic lateral sclerosis associated with a new valosin-containing protein (VCP) gene mutation." 01/01/2014 - "Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant." 05/01/2013 - "Mutations in valosin-containing protein (VCP) gene have been recently found in familial and sporadic amyotrophic lateral sclerosis (ALS). " 09/01/2012 - "We recently reported that mutations in the valosin-containing protein (VCP) gene are a cause of 1%-2% of familial amyotrophic lateral sclerosis (ALS) cases, but their role in the pathogenesis of sporadic ALS is unclear. " 09/01/2012 - "Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis."
4.	Nervous System Diseases (Neurological Disorders) 01/01/2012 - "Mutations in the valosin-containing protein gene (VCP) have been identified in neurological disorders (inclusion body myopathy--early Paget's disease of the bone--frontotemporal dementia and amyotrophic lateral sclerosis) and are thought to play a role in the clearance of abnormally folded proteins. "
5.	Neoplasms (Cancer) 01/01/2014 - "Valosin-containing protein (VCP)/p97 has been shown to be associated with antiapoptotic function via activation of the nuclear factor-[Formula: see text]B (NF[Formula: see text]B) signaling pathway and with metastasizing of tumors in several studies. " 01/01/2015 - "Valosin containing protein (VCP) is a critical mediator of protein homeostasis and may represent a valuable therapeutic target for several forms of cancer. " 05/02/2014 - "Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP)." 06/01/2008 - "Enhanced expression of valosin-containing protein (VCP) correlates with invasiveness and metastatic potential of cancer cells; therefore its transcriptional regulation could be a new target for cancer therapy. " 06/01/2008 - "E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	tau Proteins (tau Protein)
3.	Ubiquitin
4.	Proteasome Endopeptidase Complex (Proteasome)
5.	DNA-Binding Proteins (DNA Binding Protein)
6.	Transcription Factors (Transcription Factor)
7.	protein TDP-43 (TDP-43)
8.	Tubulin
9.	Oxidoreductases
10.	granulin precursor protein

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)