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carbonyl 3-chlorophenylhydrazone

inhibitor of ATP synthesis; inhibits iron-containing nitrile hydratases

Also Known As:

CCPHO; carbonyl cyanide 3-chlorophenylhydrazone; carbonyl m-chlorophenylhydrazone; m-ClCP

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrazines: 379
  - Hydrazones: 500
    - carbonyl 3-chlorophenylhydrazone: 9

Experts

1.	Cao, Jun: 1 article (06/2021)
2.	Dlamini, Mongameli B: 1 article (06/2021)
3.	Gao, Zeyun: 1 article (06/2021)
4.	Geng, Chengyan: 1 article (06/2021)
5.	Hasenbilige,: 1 article (06/2021)
6.	Jiang, Liping: 1 article (06/2021)
7.	Li, Qiujuan: 1 article (06/2021)
8.	Liu, Yong: 1 article (06/2021)
9.	Shi, Xiaoxia: 1 article (06/2021)
10.	Ahmad, Nashrah: 1 article (11/2020)

Related Diseases

1.	Bites and Stings (Sting) 11/04/2017 - "Previous study showed that carbonyl cyanide 3-chlorophenylhydrazone (CCCP), the protonophore, inhibited STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP). " 11/04/2017 - "Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) suppresses STING-mediated DNA sensing pathway through inducing mitochondrial fission."
2.	Mitochondrial Diseases (Mitochondrial Disease) 11/30/2020 - "Pharmacological induction of mitochondrial dysfunction in chondrocytes and cartilage explants using carbonyl cyanide 3-chlorophenylhydrazone increased mitochondrial superoxide production and the expression of IL-6, COX-2, MMP-3, -9, -13 and ADAMTS5, and cartilage matrix degradation. " 06/01/2021 - "Both mitochondrial dysfunction and ER stress played an important role in Cr (VI)-induced mitophagy, as the mitochondrial function inhibitor, carbonyl cyanide 3-chlorophenylhydrazone (CCCP) induced PINK1 and PARK2 and increased the expression of GRP78 and p-PERK while the levels of Cr (VI)-induced PINK1, PARK2, LC3-II were reduced after ER stress inhibitor, phenylbutyric acid (4PBA) pretreatment. "
3.	Virus Diseases (Viral Diseases) 01/01/2020 - "Here, we identified mitochondrion depolarization inducer carbonyl cyanide 3-chlorophenylhydrazone (CCCP) inhibited the response and antiviral activity of type I IFN during viral infection. "
4.	Tuberculosis (Tuberculoses) 12/01/2015 - "tuberculosis that expresses a pH-sensitive green fluorescent protein (GFP), we find that unlike the bona fide ionophores monensin and carbonyl cyanide 3-chlorophenylhydrazone, PZA and POA do not induce rapid uncoupling or cytoplasmic acidification under conditions that promote susceptibility. "
5.	Leukemia 08/15/1991 - "Aggregation of immunoglobulin E-receptor complexes on the surface of rat basophilic leukemia cells stimulates an increase in plasma membrane K+ permeability that is monitored as an increase in the rate of efflux of preloaded 86Rb+. A major component of this stimulated 86Rb+ efflux appears to be due to a Ca(2+)-activated K+ channel because it is inhibited by quinidine in parallel with the inhibition of degranulation and membrane potential repolarization, it is blocked by 0.1 mM La3+, and it is dependent on external Ca2+. Depolarization of the plasma membrane by carbonyl cyanide 3-chlorophenylhydrazone inhibits stimulated Ca2+ influx and prevents antigen-induced 86Rb+ efflux, and increased external Ca2+ partially restores 86Rb+ efflux under these conditions. "

Related Drugs and Biologics

1.	Carbonyl Cyanide m-Chlorophenyl Hydrazone (CCCP)
2.	Matrix Metalloproteinases (MMPs)
3.	Ionophores
4.	Green Fluorescent Proteins
5.	IgE Receptors (Fc epsilon RI)
6.	Interleukin-6 (Interleukin 6)
7.	Zinc
8.	Superoxides (Superoxide)
9.	Quinidine (Chinidin)
10.	Protons (Proton)