calpain inhibitor 2

inhibits degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and some other cysteine proteinases

Also Known As:

N-ALLM; N-acetyl-Leu-Leu-methioninal; N-acetylleucyl-leucyl-methioninal; SUAM-312

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - calpain inhibitor 2: 3

Experts

1.	Heino, Jyrki: 1 article (02/2008)
2.	Hyypiä, Timo: 1 article (02/2008)
3.	Marjomäki, Varpu: 1 article (02/2008)
4.	Nissinen, Liisa: 1 article (02/2008)
5.	Nylund, Camilla: 1 article (02/2008)
6.	Upla, Paula: 1 article (02/2008)
7.	Waris, Matti: 1 article (02/2008)
8.	Fukuda, S: 1 article (02/2005)
9.	Haranishi, Y: 1 article (02/2005)
10.	Kawata, R: 1 article (02/2005)

Related Diseases

1.	Traumatic Brain Injuries (Traumatic Brain Injury) 02/01/2005 - "The results suggest that moderate hypothermia, but not calpain inhibitor 2 with the tested regime, attenuates cytoskeletal damage in the ipsilateral hippocampus at 6 h after traumatic brain injury." 02/01/2005 - "We examined the therapeutic potential of calpain inhibitor 2, compared with that of moderate hypothermia in traumatic brain injury produced by weight drop in rats. " 02/01/2005 - "Moderate hypothermia, but not calpain inhibitor 2, attenuates the proteolysis of microtubule-associated protein 2 in the hippocampus following traumatic brain injury in rats." 04/01/1997 - "Spectrin breakdown products mediated by calpain 1 activation were detectable in both hemispheres 24 h after traumatic brain injury and were substantially reduced in animals treated with calpain inhibitor 2 both ipsilaterally and contralaterally to the site of injury. "
2.	Infections 02/01/2008 - "The calpain inhibitors, including calpeptin, calpain inhibitor 1, and calpain inhibitor 2 as well as calpain 1 and calpain 2 short interfering RNAs, completely blocked EV1 infection in the host cells. "
3.	Hypothermia 02/01/2005 - "The results suggest that moderate hypothermia, but not calpain inhibitor 2 with the tested regime, attenuates cytoskeletal damage in the ipsilateral hippocampus at 6 h after traumatic brain injury." 02/01/2005 - "We examined the therapeutic potential of calpain inhibitor 2, compared with that of moderate hypothermia in traumatic brain injury produced by weight drop in rats. " 02/01/2005 - "Moderate hypothermia, but not calpain inhibitor 2, attenuates the proteolysis of microtubule-associated protein 2 in the hippocampus following traumatic brain injury in rats."

Related Drugs and Biologics

1.	Calpain
2.	Spectrin
3.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
4.	calpeptin
5.	calpain inhibitors