necdin

05/01/2009 - "These studies suggest a role for Necdin in the regulation of downstream cellular targets in a hypoxic environment in virus-associated human cancers."
04/02/2013 - "Putative tumour suppressor gene necdin is hypermethylated and mutated in human cancer."
01/01/2012 - "The proposed tumor suppressor Necdin, known to be regulated by p53, was within a group of genes that was consistently upregulated in the presence of PyLT. "
01/01/2011 - "Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer."
11/01/2009 - "Necdin: a multi functional protein with potential tumor suppressor role?"

04/01/2011 - "The present studies demonstrate that the effects of necdin on the susceptibility of neuroblastoma cells to oxidant stress are dependent on the ratio of p75NTR to TrkA in the cell. "
01/16/2004 - "Overexpression of p75 translocated necdin and MAGE-G1 in the proximity of the plasma membrane and reduced their association with E2F1 to facilitate E2F1-induced death of neuroblastoma cells. "
11/01/2002 - "Necdin was undetectable in mouse neuroblastoma N1E-115 cells under undifferentiated and differentiated conditions. "
11/01/2002 - "Here we demonstrate that ectopic expression of necdin induces a neuronal phenotype in neuroblastoma cells. "
11/01/2002 - "Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells."

10/13/2015 - "Earlier studies using a mammary tumorigenesis mouse model identified Necdin (Ndn)as a germline modifier of metastasis. "
10/13/2015 - "Necdin is a breast cancer metastasis suppressor that regulates the transcription of c-Myc."
05/01/2009 - "EBNA3C can modulate the activities of the transcription factor Necdin in association with metastasis suppressor protein Nm23-H1."

01/01/2013 - "The gene for necdin, a MAGE-D1-binding protein, has been described as responsible for Prader-Willi syndrome. "
08/23/2012 - "Necdin is a growth-suppressing protein and the gene encoding it is one of several that are deleted in patients with Prader-Willi syndrome. "
04/10/2012 - "Necdin is one of several genes inactivated in children with Prader-Willi syndrome, who are predisposed to increased adiposity at the expense of lean mass. "
04/01/2011 - "Necdin deletion is associated with Prader-Willi syndrome. "
11/01/2008 - "The Prader-Willi syndrome protein necdin interacts with the E1A-like inhibitor of differentiation EID-1 and promotes myoblast differentiation."

09/01/2001 - "We have cloned the homology region between Dlxin-1 and necdin from mouse melanoma cells. "
01/01/2011 - "Further analysis of Necdin expression demonstrated repression in a STAT3-dependent manner in human melanoma, prostate and breast cancer cell lines. "
01/01/2011 - "Necdin expression has previously been shown to be down-regulated in a melanoma and a drug-resistant ovarian cancer cell line. "
01/01/2014 - "Necdin, a mammal-specific MAGE (melanoma antigen) family protein that possesses anti-mitotic and pro-survival activities, is expressed abundantly in postmitotic neurons and moderately in tissue-specific stem cells or progenitors. "
06/19/2013 - "Necdin, a MAGE (melanoma antigen) family protein, is expressed abundantly in postmitotic neurons and possesses potent antimitotic and antiapoptotic activities. "