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butixocort 21-propionate

structure given in first source

Also Known As:

JO 1222; JO-1222; Pregn-4-ene-3,20-dione, 11-hydroxy-17-(1-oxobutoxy)-21-((1-oxopropyl)thio)-, (11beta)-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Pregnanes: 9
      - Pregnenes: 1
        Pregnenediones
        butixocort 21-propionate: 1

Related Diseases

1.	Rhinitis 01/01/1991 - "These findings suggest that JO 1222 is a novel, potent, locally acting corticosteroid with little or no systemic effects and thus has therapeutical potential in diseases such as asthma, arthritis, ulcerative colitis and rhinitis."
2.	Pleurisy (Pleuritis) 01/01/1991 - "In models of acute inflammation, JO 1222 had an ED30 of 3 micrograms in carrageenan-induced oedema, an ED50 of 5 ng in croton oil-induced inflammation, and 4 micrograms and 2 micrograms/pleural cavity in carrageenin-induced pleurisy in the rat and mouse respectively. "
3.	Inflammation (Inflammations) 01/01/1991 - "In a model of subchronic inflammation JO 1222 had an ED50 of 39 micrograms/pellet (cotton pellet-induced granuloma) and an ED50 of 13 ng in oxazolone-induced hypersensitivity. " 01/01/1991 - "In models of acute inflammation, JO 1222 had an ED30 of 3 micrograms in carrageenan-induced oedema, an ED50 of 5 ng in croton oil-induced inflammation, and 4 micrograms and 2 micrograms/pleural cavity in carrageenin-induced pleurisy in the rat and mouse respectively. " 01/01/1991 - "Tixocortol 17-butyrate,21-propionate (JO 1222) is a novel, locally acting, C-21 thioester-linked corticosteroid with significant activity in a number of models of inflammation. "
4.	Hypersensitivity (Allergy) 01/01/1991 - "In a model of subchronic inflammation JO 1222 had an ED50 of 39 micrograms/pellet (cotton pellet-induced granuloma) and an ED50 of 13 ng in oxazolone-induced hypersensitivity. "
5.	Granuloma 01/01/1991 - "In a model of subchronic inflammation JO 1222 had an ED50 of 39 micrograms/pellet (cotton pellet-induced granuloma) and an ED50 of 13 ng in oxazolone-induced hypersensitivity. "

Related Drugs and Biologics

1.	Oxazolone
2.	Croton Oil
3.	Carrageenan
4.	Beclomethasone (Beclometasone)
5.	Adrenal Cortex Hormones (Corticosteroids)
6.	tixocortol
7.	compound 21