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NF-kappaB inhibitor alpha

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has I kappa B-like activity; found to specifically inhibit the DNA-binding activity of the p50/p65 NF-kappa B complex but not that of other DNA-binding proteins

Also Known As:

I kappa B-alpha protein; IkappaB-alpha; IkappaBalpha; NFKBIA protein, human; Nfkbia protein, mouse; Nfkbia protein, rat; RL-IF-1 protein, rat; major histocompatibility complex enhancer-binding protein MAD3; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha protein, human; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha protein, rat; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha protein, mouse; p40 protein (IkappaB-alpha); regenerating liver inhibitory factor-1 protein, rat

Networked: 567 relevant articles (14 outcomes, 45 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
- Peptides: 22950
  - Intracellular Signaling Peptides and Proteins: 22
    - I-kappa B Proteins: 131
      - NF-kappaB inhibitor alpha: 567

Experts

1.	Wong, Hector R: 7 articles (09/2008 - 02/2002)
2.	Squadrito, Francesco: 6 articles (07/2008 - 01/2002)
3.	Altavilla, Domenica: 6 articles (07/2008 - 01/2002)
4.	Minutoli, Letteria: 5 articles (07/2008 - 02/2003)
5.	Shanley, Thomas P: 5 articles (03/2004 - 02/2002)
6.	Aggarwal, Bharat B: 4 articles (04/2010 - 05/2004)
7.	Dou, Q Ping: 4 articles (11/2008 - 07/2002)
8.	Baldwin, Albert S: 4 articles (02/2008 - 02/2003)
9.	Squadrito, Giovanni: 4 articles (05/2006 - 01/2002)
10.	Venuti, Francesco S: 4 articles (05/2006 - 02/2003)

Related Diseases

1.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 03/01/2009 - "In this study, we show that transgenic inactivation of astroglial NF-kappaB (glial fibrillary acidic protein-IkappaB alpha-dominant-negative mice) resulted in reduced disease severity and improved functional recovery following experimental autoimmune encephalomyelitis. " 12/10/2009 - "Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex."
2.	Reperfusion Injury 06/01/2005 - "Adenoviral transfer of the IkappaBalpha SR gene in the liver ameliorates short term warm ischaemia/reperfusion injury, possibly through attenuation of hepatic macrophage activation." 08/01/2003 - "Gene transfer of IkappaBalpha limits infarct size in a mouse model of myocardial ischemia-reperfusion injury." 07/01/2004 - "Inhibition of nuclear translocation of NF-kappaB by IkappaBalpha phosphorylation blockade could provide an effective approach to attenuation of ischemia/reperfusion injury. " 01/01/2007 - "Paradoxically, degradation of IkappaB proteins, IkappaB-alpha and IkappaB-beta, was greatest in the normothermic group, suggesting an alternate NF-kappaB regulatory mechanism during ischemia-reperfusion injury. " 06/01/2005 - "Gene transfection with IkappaBalpha SR, but not with LacZ, markedly attenuated ischaemia/reperfusion injury, suppressing inducible nitric oxide synthase and nitrotyrosine expression in the liver. "
3.	Neoplasms (Cancer) 01/01/2012 - "The current study examines associations between polymorphisms within promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IkappaBalpha (IκBα) with both the susceptibility to develop OSCC and the clinicopathological characteristics of the tumors. " 03/01/2010 - "These data suggest that the impairment of the IkappaBalpha functions was produced during the pathogenesis of the tumor cell clone in Chinese HL patients." 01/01/2010 - "In addition, expression of the inhibitor of kappa B alpha (IkappaBalpha) was decreased by 25% in cancer patients. " 04/01/2009 - "Expression of p65 and phosphorylated IkappaBalpha are high in tumors from TRAMP mice. " 01/09/2009 - "Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions."
4.	Ischemia 11/01/2012 - "The 36 rats were divided randomly into 3 groups: (A) recombinant adenovirus expressing wild-type κBα(AdIκBαM) group, (B) recombinant adenovirus expressing wild-type IkappaBalpha (AdIκBα) group, and (C) simple ischemia group. " 10/09/2008 - "GKAB blocked ischemia-induced increases in p-NIK and p-IKKalpha levels, and reversed the decline in IkappaBalpha levels. " 04/01/2008 - "A brief increase in pIKKalpha levels and rapid reduction in IkappaBalpha were observed after ischemia. " 01/01/2008 - "In contrast, the level and expression of IkappaB-alpha protein decreased 1 h after ischemia-reperfusion and recovered to the normal level by microinjection of Ang II into the PVN. " 04/12/2002 - "Decrement of IkappaB-alpha was found after 3 h reperfusion in the cytoplasm following global ischemia, which was also blocked by such three antagonists. "
5.	Wounds and Injuries (Trauma) 12/15/2002 - "Interestingly, constitutive activation of NFkappaB following Ad.IkappaBalphaAS infection reduced apoptosis only following injuries associated with IkappaBalpha Y42, but not S32/36, phosphorylation. " 01/05/2006 - "Compared to younger (8 weeks) mice, older (18 months) mice exposed to O(3) (day 0 to day 9 after wounding) exhibited delayed wound closure, increased lipid peroxidation (measured as 4-HNE protein adducts) and protein oxidation (measured as carbonyls concentration) and decreased levels of P-IkappaBalpha and TGFbeta protein. " 03/01/2003 - "This study examined the effects of either IkappaBalpha overexpression (transgenic mice) or N-acetyl-leucinyl-leucinyl-norleucinal (ALLN) administration (proteosome inhibitor in wild-type mice) on cardiomyocyte secretion of tumor necrosis factor-alpha (TNF-alpha) and on cardiac performance after burn trauma. " 11/01/2000 - "The reduced expression of nuclear NF-kappaB was not due to its inhibition by IkappaBalpha, as very low expression of IkappaBalpha, as well as low levels of p65 and p50 were found in the cytoplasm of PBMC from patients with sepsis and trauma when compared with control subjects. " 11/01/2004 - "Inhibiting IkappaBalpha blocked trauma-induced NF-kappaB activity, COX-2 expression and PGE2 production. "

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
3.	DNA (Deoxyribonucleic Acid)
4.	I-kappa B Kinase
5.	Proteasome Endopeptidase Complex (Proteasome)
6.	Glucocorticoid Receptors (Glucocorticoid Receptor)
7.	Glial Fibrillary Acidic Protein
8.	Interleukin-6 (Interleukin 6)
9.	Tyrosine (L-Tyrosine)
10.	alpha-MSH

Related Therapies and Procedures

1.	Induced Hypothermia
2.	Oral Administration
3.	Drug Therapy (Chemotherapy)
4.	Heterologous Transplantation (Xenotransplantation)
5.	Transplants (Transplant)