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M 8506

RN given for oxalate (1:1) salt; RN for parent cpd not available 8/91

Also Known As:

M 8506 oxalate salt; M-8506; trifluoroacetylprimaquine

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Aminoquinolines: 29
        Primaquine: 1165
        M 8506: 1

Related Diseases

1.	Malaria 07/01/1990 - "Because M-8506 is less toxic than primaquine in mice and more effective in radical treatment of simian malaria, further studies on trifluoroacetyl primaquine are worthy to be considered."
2.	Parasitemia 07/01/1990 - "The parasitemia reappeared earlier than that treated with M-8506 0.75 mg/(kg.d) x 3 d and relapsed on d 62. " 07/01/1990 - "on d 1. M-8506 at 0.75, 1.5 and 3 mg/(kg.d) x 3d plus pyronaridine were given to 7, 4 and 2 infected monkeys with parasitemia respectively. "
3.	Infections 07/01/1990 - "In P yoelii sporozoite infected mice, the protection rates with ig M-8506 5, 10 and 20 mg (base)/kg on the day of infection were 56.7, 87.2 and 100%, respectively. "

Related Drugs and Biologics

1.	Primaquine
2.	pyronaridine