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E 5090

orally active inhibitor of IL-1 generation

Also Known As:

3-(4-(acetyloxy)-5-ethyl-3-methoxy-1-naphthalenyl)-2-methyl-2-propenoic acid; E-5090; E5090

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Naphthols: 64
        E 5090: 2
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acrylates: 212
      - E 5090: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Naphthols: 64
      - E 5090: 2

Related Diseases

1.	Pain (Aches) 01/01/1991 - "E5090 was effective in acute inflammatory models such as carrageenin-induced paw edema, and adjuvant-induced local hyperthermia, and also showed analgesic effects against inflammatory pain and antipyretic effects. "
2.	Edema (Dropsy) 01/01/1991 - "E5090 was effective in acute inflammatory models such as carrageenin-induced paw edema, and adjuvant-induced local hyperthermia, and also showed analgesic effects against inflammatory pain and antipyretic effects. "
3.	Granuloma 01/01/1991 - "A novel inhibitor of IL-1 generation, E5090: in vivo inhibitory effect on the generation of IL-1-like factor and on granuloma formation in an air-pouch model."
4.	Experimental Arthritis 01/01/1991 - "In adjuvant arthritis, E5090 suppressed both the paw swelling and the enhancements of ESR and number of peripheral blood leucocytes, like the steroidal antiinflammatory drug prednisolone. "
5.	Arthritis (Polyarthritis) 01/01/1991 - "In type II collagen-induced arthritis, E5090 inhibited paw swelling and joint destruction. "

Related Drugs and Biologics

1.	Antipyretics
2.	Carrageenan
3.	Analgesics (Analgesic Drugs)
4.	Collagen Type II (Type II Collagen)
5.	Prednisolone (Predate)
6.	Interleukin-1 (Interleukin 1)

Related Therapies and Procedures

1.	Induced Hyperthermia (Thermotherapy)