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quetiapine (Seroquel)

Also Known As:

Seroquel; quetiapine fumarate; 2-(2-(4-dibenzo(b,f)(1,4)thiazepine-11-yl-1-piperazinyl)ethoxy)ethanol; AstraZeneca Brand of Quetiapine Fumarate; Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-, (E)-2-butenedioate (2:1) (salt); ICI 204,636; ICI 204636; ICI-204636; Zeneca Brand of Quetiapine Fumarate

Networked: 1827 relevant articles (297 outcomes, 603 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Eriksson, Hans: 31 articles (05/2015 - 03/2009)
2.	Vieta, Eduard: 27 articles (02/2014 - 10/2002)
3.	Brecher, Martin: 26 articles (05/2010 - 07/2003)
4.	Calabrese, Joseph R: 23 articles (10/2015 - 11/2004)
5.	Paulsson, Björn: 20 articles (02/2014 - 12/2004)
6.	Citrome, Leslie: 19 articles (12/2014 - 09/2004)
7.	Li, Xin-Min: 18 articles (02/2015 - 11/2005)
8.	McIntyre, Roger S: 17 articles (12/2015 - 11/2003)
9.	Ketter, Terence A: 16 articles (05/2015 - 07/2005)
10.	Leucht, Stefan: 16 articles (01/2014 - 04/2007)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 04/01/1999 - "From these results, quetiapine fumarate was suggested to be highly effective and safe for the treatment of schizophrenia." 04/01/2007 - "The efficacy of quetiapine in reducing positive and negative symptoms of schizophrenia has been proven in several clinical trials with placebo-controlled comparators. " 01/01/2011 - "Quetiapine is an atypical antipsychotic with proven efficacy and an established tolerability profile in schizophrenia. " 07/01/2003 - "Quetiapine, an atypical antipsychotic with proven efficacy in the treatment of psychotic symptoms in schizophrenia, also has efficacy for treating depressive symptoms in patients with schizophrenia and other psychiatric disorders. " 10/01/2001 - "Quetiapine is a novel atypical antipsychotic with proven efficacy in schizophrenia across all domains. "
2.	Bipolar Disorder (Mania) 01/01/2007 - "Quetiapine as monotherapy, or in combination with Li or DVP, was a highly effective treatment for acute mania, as shown by overall change scores in the total YMRS. " 01/01/2007 - "Quetiapine was associated with significantly higher response and remission/euthymia rates compared with placebo with most criteria used, in patients with acute mania at the end of both 3 and 12 weeks." 01/01/2012 - "In bipolar disorder, quetiapine XR has also proven effective in relieving acute depressive and manic symptoms. " 12/01/2008 - "Quetiapine monotherapy is effective in improving impairment in important aspects of life that accompany improvements in depressive symptoms in patients with acute bipolar depression." 01/01/2013 - "In this 3-week study, quetiapine was significantly more effective than placebo in improving manic symptoms in youth with mania associated with bipolar disorder. "
3.	Psychotic Disorders (Schizoaffective Disorder) 10/01/2004 - "The administration of quetiapine in doses of 25-50 mg/day brought about an important improvement in the control over the signs of parkinsonian psychoses in our patients. " 01/01/2001 - "Quetiapine is suggested to be effective treatment of youths with psychotic disorders and to have a favorable side-effect profile." 01/01/2007 - "In line with other studies, quetiapine may be considered as an effective treatment for adolescents with a severe psychotic disorder showing a favourable side-effect profile. " 04/01/2000 - "This is the first investigation of the pharmacokinetics, tolerability, and efficacy of quetiapine fumarate in adolescents with chronic or intermittent psychotic disorders. " 04/01/2015 - "The atypical antipsychotic quetiapine has been used in different psychotic and non-psychotic disorders in children and adolescents in randomized clinical trials, open-label studies and chart reviews. "
4.	Sleep Initiation and Maintenance Disorders (Insomnia) 06/01/2014 - "A time × drug interaction was seen for the subjective insomnia, such that quetiapine XR-treated subjects reported greater initial improvement in their subjective insomnia, but the difference was not sustained. " 01/01/2009 - "Quetiapine has been demonstrated in open-label trials to be effective for the treatment of insomnia and VH in PD. " 12/01/2006 - "As the studied patients with depression showed improvement in subjective and objective sleep parameters, quetiapine may be a promising drug for patients with depression and insomnia. " 07/01/2005 - "These results suggest that quetiapine may be a safe and effective treatment of insomnia in PD patients. " 03/01/2014 - "Robust studies evaluating the safety and efficacy of quetiapine for the treatment of insomnia are lacking. "
5.	Major Depressive Disorder (Major Depressive Disorders) 12/01/2009 - "Taken together, extant studies demonstrated that quetiapine XR (50 - 300 mg) provides rapid and sustained symptomatic improvement in the acute and maintenance treatment of major depressive disorder. " 01/01/2012 - "Efficacy of extended release quetiapine fumarate monotherapy in patients with major depressive disorder: a pooled analysis of two 6-week, double-blind, placebo-controlled studies." 12/01/2015 - "The aim of this post-hoc analysis was to determine whether early symptom improvement with extended release quetiapine (quetiapine XR) may predict treatment outcome in patients with major depressive disorder. " 05/01/2015 - "Analysis of potentially predictive factors of efficacy of adjunct extended-release quetiapine fumarate in patients with major depressive disorder." 05/01/2013 - "The efficacy of quetiapine XR was investigated in patients with major depressive disorder and differing levels of baseline severity. "

Related Drugs and Biologics

1.	olanzapine (Zyprexa)
2.	Antipsychotic Agents (Antipsychotics)
3.	Risperidone (Risperdal Consta)
4.	quetiapine (Seroquel)
5.	ziprasidone (Geodon)
6.	aripiprazole (Abilify)
7.	Clozapine (Clozaril)
8.	Haloperidol (Haldol)
9.	Lithium
10.	Valproic Acid (Valproate, Semisodium)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Drug Therapy (Chemotherapy)
3.	Injections
4.	Polypharmacy
5.	Length of Stay