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multimerin

protein which exhibits a complex, disulfide-linked multimeric composition with variability in multimere size

Also Known As:

platelet protein p-155

Networked: 16 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - multimerin: 16

Experts

1.	Hayward, Catherine P M: 2 articles (01/2021 - 05/2010)
2.	Ni, Heyu: 2 articles (01/2021 - 05/2010)
3.	Tasneem, Subia: 2 articles (01/2021 - 05/2010)
4.	Hayward, C P: 2 articles (06/2001 - 02/2001)
5.	Lages, B: 2 articles (06/2001 - 02/2001)
6.	Weiss, H J: 2 articles (06/2001 - 02/2001)
7.	Zheng, S: 2 articles (06/2001 - 02/2001)
8.	Arendarczyk, Adam: 1 article (01/2021)
9.	Bihan, Dominique: 1 article (01/2021)
10.	Bonna, Arkadiusz: 1 article (01/2021)

Related Diseases

1.	Thrombosis (Thrombus) 05/01/2010 - "Multimerin 1/alpha-synuclein deficient mice showed impaired platelet adhesion and their defective thrombus formation at sites of vessel injury improved with multimerin 1 transfusion. " 01/01/2021 - "Multimerin 1 supports platelet adhesion and thrombus formation and binds to highly conserved, GPAGPOGPX motifs in fibrillar collagens that synergistically enhance platelet adhesion." 05/01/2010 - "Mice with deleted multimerin 1 and alpha-synuclein genes have impaired platelet adhesion and impaired thrombus formation that is corrected by multimerin 1." 05/01/2010 - "Although multimerin 1/alpha-synuclein deficient platelets showed increased P-selectin release at low thrombin concentrations, they also showed impaired adhesion to collagen, and attenuated aggregation with thrombin, that improved with added multimerin 1. Our data suggest that multimerin 1 supports platelet adhesive functions and thrombus formation, which will be important to verify by generating and testing selective multimerin 1 deficient mice."
2.	von Willebrand Diseases (von Willebrand's Disease) 10/01/1998 - "Studies of multimerin in patients with von Willebrand disease and platelet von Willebrand factor deficiency."
3.	Factor V Deficiency 06/15/1996 - "Recent studies identified multimerin as a specific coagulation factor V binding protein, complexed with platelet, but not plasma, factor V. These findings led us to investigate individuals with inherited factor V deficiencies for possible multimerin abnormalities. "
4.	deficiency Von willebrand factor 10/01/1998 - "Studies of multimerin in patients with von Willebrand disease and platelet von Willebrand factor deficiency."
5.	Hemorrhage 06/01/1997 - "Recently, members of 2 Canadian families with puzzling autosomal-dominant bleeding disorders were found to have a deficiency of platelet multimerin. " 02/15/1997 - "We recently described a Quebec family with an autosomal dominant bleeding disorder characterized by mildly reduced-low normal platelet counts, an epinephrine aggregation defect, multimerin deficiency, and proteolytic degradation of several, soluble alpha-granular proteins. " 06/15/1996 - "These data indicate that patients with factor V Quebec have an inherited bleeding disorder distinct from other platelet disorders and associated with multiple abnormalities, including multimerin deficiency, abnormal platelet factor V, thrombospondin, von Willebrand factor, and fibrinogen, and an epinephrine aggregation defect."

Related Drugs and Biologics

1.	alpha-Synuclein
2.	P-Selectin
3.	Thrombin
4.	Collagen
5.	Factor V (Coagulation Factor V)
6.	Carrier Proteins (Binding Protein)
7.	Proteins (Proteins, Gene)
8.	Fibrinogen (Factor I)
9.	Epinephrine (Adrenaline)
10.	elastin microfibril interface located protein (emilin)