Tyr(5)-Trp(6,8,9)-Lys(10)- neurokinin A(4-10)

tachykinin receptor antagonist

Also Known As:

neurokinin A(4-10), Tyr(5)-Trp(6,8,9)-Lys(10)-; 5-Tyr-6,8,9-Trp-10-Lys-neurokinin A (4-10); MEN 10376; MEN-10,376; neurokinin A(4-10), tyrosyl(5)-tryptophyl(6,8,9)-lysine(10)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Kinins: 2029
      - Tachykinins: 869
        Neurokinin A: 269
        Tyr(5)-Trp(6,8,9)-Lys(10)- neurokinin A(4-10): 3
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Tachykinins: 869
        Neurokinin A: 269
        Tyr(5)-Trp(6,8,9)-Lys(10)- neurokinin A(4-10): 3
- Peptides: 82426
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Kinins: 2029
    - Tachykinins: 869
      - Neurokinin A: 269
        Tyr(5)-Trp(6,8,9)-Lys(10)- neurokinin A(4-10): 3
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Kinins: 2029
      - Tachykinins: 869
        Neurokinin A: 269
        Tyr(5)-Trp(6,8,9)-Lys(10)- neurokinin A(4-10): 3

Experts

1.	Bongianni, Fulvia: 1 article (07/2008)
2.	Cinelli, Elenia: 1 article (07/2008)
3.	Fontana, Giovanni A: 1 article (07/2008)
4.	Mutolo, Donatella: 1 article (07/2008)
5.	Pantaleo, Tito: 1 article (07/2008)

Related Diseases

1.	Shock 06/01/1994 - "In naive animals the prolonged VRP evoked following single shock C-fiber stimulation was significantly antagonized by the NMDA receptor antagonist D-AP5 and the NK2 receptor antagonist MEN, 10376 but not by the NK1 receptor antagonists CP-96,345 or RP,67580. "
2.	Hypersensitivity (Allergy) 08/01/1995 - "Pretreatment with RP 67580 but not MEN 10376 prevented this, but when RP 67580 was administered 25 min after the application of mustard oil, the established hypersensitivity of the flexor motor reflex was not reversed. " 08/01/1995 - "3. Injection of bradykinin (60 microM, 80 microliters) into the gastrocnemius muscle increased the cutaneous mechanical hypersensitivity of PBF-ST flexor motoneurones for 40-50 min. MEN 10376, but not RP 67580, prevented this, but only when administered prior to the bradykinin injection. "
3.	Hyperalgesia 08/01/1995 - "This cutaneous mechanical reflex allodynia was prevented by pretreatment with the NK1 antagonist RP 67580 (2.28 nmol, i.t.) and the NK2 antagonist MEN 10376 (0.7 nmol, i.t.), respectively. "
4.	Cough 07/01/2008 - "The neurokinin-1 (NK1) receptor antagonist CP-99,994 (10 mM) abolished cough responses, whereas the NK2 receptor antagonist MEN 10376 (5 mM) had no effect. "

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