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pertactin

amino acid sequence has been determined; synthesized as a 93kDa precursor; mature pertactin is 68kDa in B. pertussis, 69kDA in B. bronchiseptica, and 70kDA in B. parapertussis

Also Known As:

Bordetella pertussis outer membrane protein P69; OMP p.68, B. bronchiseptica; OMP p.69, B. pertussis; OMP p.70, B. parapertussis; P.70 pertactin; P70 pertactin; PRN protein, Bordetella bronchiseptica; p.68 pertactin; pertactin p.68; pertactin, Bordetella bronchiseptica; pertactin, Bordetella parapertussis

Networked: 215 relevant articles (12 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	McIntyre, Peter: 6 articles (11/2015 - 01/2010)
2.	Guiso, Nicole: 6 articles (01/2015 - 11/2005)
3.	Marshall, Helen: 5 articles (11/2015 - 01/2010)
4.	He, Qiushui: 5 articles (01/2014 - 07/2004)
5.	Pichichero, Michael E: 5 articles (11/2013 - 06/2005)
6.	Berbers, Guy A M: 5 articles (02/2011 - 08/2007)
7.	Mooi, Frits R: 5 articles (01/2011 - 06/2002)
8.	Van Damme, Pierre: 4 articles (01/2016 - 06/2003)
9.	Zhang, Shumin: 4 articles (01/2014 - 01/2006)
10.	van Els, Cécile A C M: 4 articles (01/2014 - 02/2009)

Related Diseases

1.	Whooping Cough (Pertussis) 11/01/1995 - "Our subgroup data suggest that high values of antibody to pertactin and high agglutinin titers may be predictive of protection against clinical pertussis." 12/15/2001 - "We conclude that 2 studies have shown correlates between measurable anti-pertactin, anti-fimbriae, and anti-PT antibody levels at exposure and individual protection against pertussis. " 12/15/2001 - "However, in household studies nested in 2 recent trials, preexposure antibody levels against pertactin and against fimbriae correlated with protection against typical and mild pertussis, and anti-PT correlated only with protection against typical pertussis. " 11/17/2015 - "pertussis strains that do not express pertactin (Prn), a key antigenic component of the ACV, have emerged and become prevalent. " 08/01/2015 - "Pertussis Resurgence Associated with Pertactin-Deficient and Genetically Divergent Bordetella Pertussis Isolates in Israel."
2.	Diphtheria 09/01/2008 - "Compared with the control group, infants in the experimental group demonstrated significantly lower geometric mean antibody concentrations for pertussis toxin and pertactin 6, 7, and 18 months, for fimbrae at 6, 7, 17, and 18 months, and for FHA at 18 months, and lower geometric mean antibody concentrations for diphtheria at 7 months. " 09/08/2003 - "GMCs for other vaccine antigens were comparable between groups except for diphtheria (higher in the 7VPnC group) and pertactin (lower in the 7VPnC group), although after three vaccine doses there was a 28-fold rise in GMCs from baseline. " 06/06/2011 - "Immunogenicity was assessed pre and post vaccination by ELISA for diphtheria (D), tetanus (T), pertussis toxin (PT), filamentous haemagglutinin (FHA), and pertactin (PRN). " 01/01/2006 - "Significantly higher anti-diphtheria, anti-pertactin (PRN) and anti-polio GMTs were measured following DTPa-HBV-IPV than DTPa-HBV plus IPV. " 01/01/2004 - "After the third immunisation, preterm infants had similar GMCs to controls to diphtheria, tetanus, filamentous haemagglutinin (FHA), and pertactin (PRN), but a significantly lower GMC to pertussis toxin (PT). "
3.	Tetanus 02/04/2011 - "Purified B-cells were characterized by FACS-analysis and after polyclonal stimulation memory B-cells were detected by ELISPOT-assays specific for pertussis toxin, filamentous haemagglutinin, pertactin and tetanus. " 06/06/2011 - "Immunogenicity was assessed pre and post vaccination by ELISA for diphtheria (D), tetanus (T), pertussis toxin (PT), filamentous haemagglutinin (FHA), and pertactin (PRN). " 01/01/2004 - "After the third immunisation, preterm infants had similar GMCs to controls to diphtheria, tetanus, filamentous haemagglutinin (FHA), and pertactin (PRN), but a significantly lower GMC to pertussis toxin (PT). " 05/01/1994 - "Antibody responses to PT, FHA, pertactin, and diphtheria and tetanus toxoids were measured by enzyme-linked immunosorbent assay. " 01/01/1992 - "The molecule has been tested alone, combined with FHA and pertactin and also combined with diphtheria and tetanus toxoids.(ABSTRACT TRUNCATED AT 250 WORDS)"
4.	Infection 11/17/2015 - "Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model." 07/01/2000 - "Antibody patterns over time suggest that antibody to FHA and perhaps to pertactin is stimulated by infections with other organisms, as well as B. " 12/01/1998 - "Subjects with an imputed pertactin value of < 7 EU ml-1 had a 67% (18/27) chance of infection regardless of the PT value. " 12/01/1998 - "The imputed geometric mean antibody values to PT, pertactin and fimbriae-2 at the time of household exposure to Bordetella pertussis infection were higher (p < 0.07 or lower) in non-cases compared with cases. " 01/01/1992 - "Recombinant P.69/pertactin: immunogenicity and protection of mice against Bordetella pertussis infection."
5.	Cough 07/01/2003 - "In the present study, IgG antibodies against pertactin, pertussis toxin and FHA (determined by ELISA) were compared in 207 individuals with culture-verified pertussis and paroxysmal cough for >/= 21 days. " 04/01/1997 - "When analyzing efficacy based on prevention of laboratory-confirmed pertussis with cough > or = 7 days, single component pertussis toxin (PT) toxoid vaccines were found to be less effective than two-component PT toxoid/filamentous hemagglutinin vaccines, and three- or four-component vaccines containing pertactin in addition to PT toxoid and filamentous hemagglutinin were more effective than either the single-component or two-component vaccines."

Related Drugs and Biologics

1.	Hemagglutinins (Hemagglutinin)
2.	pertussis toxoid
3.	Pertussis Toxin
4.	Vaccines
5.	Antigens
6.	Diphtheria-Tetanus-acellular Pertussis Vaccines (Tripedia)
7.	Pertussis Vaccine
8.	Toxoids
9.	Antibodies
10.	adacel