miltirone

04/15/2016 - "In this study, ROS- and p53-dependent apoptosis induced by miltirone on colon cancer cells was firstly revealed. "
04/15/2016 - "To study the characteristics of miltirone-induced anti-colon cancer effects. "
04/15/2016 - "Miltirone exhibited potent cytotoxicity on colon cancer cells with a better selectivity than that of dihydrotanshinone. "
04/15/2016 - "Strong positive feedback between mitochondrial dysfunction and accumulation of intracellular Ca(2+) was suggested to be the characteristic of the anti-colon cancer activity of miltirone."
04/15/2016 - "Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells."

02/05/2016 - "In this study, we investigated the effects of miltirone in human leukemia cell lines, primary leukemia cells, and nude mice U937 xenograft. "
05/01/2022 - "A total of 26 targets of miltirone, 1 046 genes related to acute leukemia, and 6 common targets of the two were screened out. "
05/01/2022 - "[Effect of miltirone on proliferation and apoptosis of leukemia THP-1 cells]."
02/05/2016 - "In contrast, treatment with ER stress inhibitor TUDCA significantly attenuated miltirone-induced ROS and apoptosis in leukemia cells. "

08/01/2020 - "Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis."
09/25/2015 - "Thus, we conclude that miltirone (1) is a dual inhibitor of P-gp and cell growth in human drug-resistant hepatoma cells. "
09/25/2015 - "Results of the current study suggest a dual effect of miltirone on P-gp inhibition and apoptotic induction in a human hepatoma HepG2 cell line and its P-gp-overexpressing doxorubicin-resistant counterpart (R-HepG2). "
08/01/2020 - "Here, we found that miltirone inhibited the cell viability of either HepG2 or Hepa1-6 cells, and induced the proteolytic cleavage of gasdermin E (GSDME) in each hepatocellular carcinoma (HCC) cell line, with concomitant cleavage of caspase 3. Knocking out GSDME switched miltirone-induced cell death from pyroptosis to apoptosis. "

10/01/2022 - "Our study aimed to explore the protective effect of miltirone on 1-methyl-4-phenylpyridinium (MPP+)-induced cell model of Parkinson's disease (PD). "
10/01/2022 - "Miltirone Attenuates Reactive Oxygen Species-Dependent Neuronal Apoptosis in MPP+-Induced Cell Model of Parkinson's Disease Through Regulating the PI3K/Akt Pathway."

06/01/2018 - "The results of the present study demonstrated that miltirone induces apoptosis in cisplatin-resistant lung cancer cells through ROS-p53, AIF, PARP and MMP2/9 signaling pathways."
06/01/2018 - "The present study aimed to examine the anticancer effect of miltirone in cisplatin-resistant lung cancer cells. "
06/01/2018 - "Treatment with miltirone suppressed cell viability and induced apoptosis in HCC827 and A549 platinum-resistant lung cancer cells. "
06/01/2018 - "The effect of miltirone on cisplatin-resistant lung cancer cells has not been investigated to date. "
06/01/2018 - "Miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways."